Cellular Respiration

Cellular Respiration - BILD1 Cellular Respiration Energy...

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BILD1 Cellular Respiration
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Light energy ECOSYSTEM CO 2 + H 2 O Photosynthesis in chloroplasts Cellular respiration in mitochondria Organic molecules + O 2 ATP powers most cellular work Heat energy Energy flow and chemical recycling in ecosystems Today’s lecture
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Cellular Respiration C 6 H 12 O 6 + 6 O 2 6 CO 2 + 6 H 2 O + E (ATP + Heat) ΔG = -686 kcal Energy-releasing pathway used by the cell to break down organic fuels like glucose using O 2 and a series of steps to efficiently extract energy. There are over 20 enzymes and steps involved in this process Goal = to generate ATP, the energy currency of the cell.
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Electrons carried via NADH Glycolsis Glucose Pyruvate ATP Substrate-level phosphorylation Electrons carried via NADH and FADH2 Citric acid cycle Oxidative phosphorylation: electron transport and chemiosmosis ATP ATP Substrate-level phosphorylation Oxidative phosphorylation Mitochondrion An overview of cellular respiration
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Three stages of cellular respiration: 1. Glycolysis: Splits Glucose into two pyruvate molecules; occurs in cytosol; does NOT require O 2 1. Citric Acid Cycle (Krebs Cycle): Completes breakdown of glucose; occurs in Mitochondrial matrix. 1. Oxidative Phosphorylation: Generates the vast majority of ATP. Occurs in Mitochondrial inner membrane. Driven by electron transport chain O 2 ultimate acceptor of the electrons derived from breakdown of glucose. Chemiosmosis couples ETC to ATP production. CELLULAR RESPIRATION
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Review of Mitochondria, sites of cellular respiration Enclosed by two membranes : Inner membrane is highly convoluted into infoldings termed cristae . This provides high surface area for enzymes localized in the inner membrane. Enhances efficiency of cellular respiration. Contains a mitochondrial genome separate from nucleus. Inner membrane Outer membrane Intermembrane space genome matrix
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Mitochondrial DNA Science , vol 319, 15 Feb 2008, pg 915 Maternally inherited Mutations cause many diseases: Kearns–Sayre syndrome (KSS), LHON, OPHTHALMOPLEGIA, PEARSON SYNDROME, LEIGH SYNDROME, exercise-induced muscle pain, fatigue and RHABDOMYOLYSIS, and aminoglycoside-induced hearing loss.
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An overview of respiration: Notice the proton gradient in the intermembrane space
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Cellular Respiration - BILD1 Cellular Respiration Energy...

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