web_L26_08BIO311C - BIO 311C March 26, 2008 dehydrogenase...

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Unformatted text preview: BIO 311C March 26, 2008 dehydrogenase Complete reaction: R-CH 2 OH + NAD + R-CHO + NADH + H + Typical Reaction Involving the Reduction of NAD + * (half-reaction) oxidation of an alcohol (half-reaction) reduction of NAD + Dehydrogenase Reaction 1 (oxidation of an alcohol) Reaction 2 (reduction of a disulfide) NAD + acts as a carrier of reducing units in living cells. NAD + acquires two reducing units in Reaction 1. NADH donates two reducing units in Reaction 2. * Sum of the Reactions 1 and 2: 3 3 3 R 3 CH 2 OH + R 1-S-S-R 2 R 3 CHO + R 1-SH + R 2 SH Reaction 1 (oxidation of an alcohol) Reaction 2 (reduction of a disulfide) Reactions 1 and 2 from the Previous Presentation Slide, Shown in a Slightly Different Way * net: aldehyde + R 1-SH + R 2-SH alcohol + R 1-S-S-R 2 enz. 1, enz. 2 * An alcohol is oxidized and a disulfide is reduced. Two separate metabolic reactions can be shown as one continuous process when both reactions occur in one compartment and a product of one reaction is a reactant the other reaction. Reactions 1 and 2 from the Previous Presentation Slide, Shown as One Continuous Process Other Important Hydrogen-atom Carriers in Cells NADPH NADP + [2H ] H + NADP + + [ 2H ] NADPH + H + FADH 2 FAD [2H ] FAD + [ 2H ] FADH 2 * Structure of NADP + Nucleotide 2 (NMP) Nucleotide 1 (AMP with an extra phosphate) The extra phosphate on NADP + allows each enzyme that catalyzes a redox reaction to distinguish NADP + from NAD + (which doesn’t carry the extra phosphate). Thus NAD + and NADP + can function in distinct metabolic reactions, even though they occur in the same cellular compartment and function in the same way. * Review Requirements of Metabolic Reactions- Each reaction must proceed in the right direction; i.e....
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This note was uploaded on 09/28/2008 for the course BIO 311C taught by Professor Satasivian during the Spring '08 term at University of Texas at Austin.

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web_L26_08BIO311C - BIO 311C March 26, 2008 dehydrogenase...

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