web_L29_08BIO311C - BIO 311C April 2, 2008 Principle of...

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Unformatted text preview: BIO 311C April 2, 2008 Principle of Operation of an Electron Transport Chain to Generate a Proton Gradient Across a Membrane The carriers of reducing units alternate between hydrogen-atom carriers and electron carriers. Whenever protons are needed, they are withdrawn from one side of the membrane; whenever protons are produced, they are released to the other side of the membrane. Thus a difference in pH and in electric charge is generated across the membrane. * Component A is an electron carrier. Component B is a hydrogen-atom carrier. A proton is released into the intermembrane space when the electrons from NADH are transferred to Component A. Protons are withdrawn from the matrix when hydrogen atoms are transferred to Component B. * Initial Components of the Electron-transport Chain of the Mitochondrial Inner Membrane FADH 2 also donates electrons to an electron transport chain of the mitochondrial inner membrane. * Reducing units from FADH 2 that are used in the electron transport cause the H + concentration in intermembrane space to increase and the H + concentration in the matrix to decrease. Electrons entering the mitochondrial electron transport chain from either NADH or FADH 2 are ultimately transferred to O 2 which, along with protons drawn from the matrix, reduce the O 2 to water. * Protons are removed from the matrix during electron transport to water, making the matrix more alkaline with respect to the intermembrane space. Illustration of Proton Transport Across the Mitochondrial Inner Membrane During Mitochondrial Electron Transport Also textbook Fig. 9.15, p. 172 * intermembrane space becomes acidic matrix becomes basic Is mitochondrial electron transport a metabolic pathway? mitochondrial inner membrane Function of ATP Synthase in the Mitochondrial Inner Membrane From textbook Fig. 9.15, p. 172 intermembrane space matrix Mitochondrial electron transport causes a higher concentration of H + on this side...
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web_L29_08BIO311C - BIO 311C April 2, 2008 Principle of...

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