web_L28_08BIO311C - BIO 311C March 31, 2008 Phase 2 of...

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BIO 311C March 31, 2008
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Phase 2 of Glycolysis: 2 of glycolysis Phase 2 4 ADP + 2 P i 2 NAD + 4 ATP 2 (NADH + H + ) glyceraldehyde-3-phosphate (gly-3-P) Two molecules of substrate are considered instead of one, since two gly-3-P are produced for every glucose molecule that enters glycolysis. * 2 of pyruvate (pyr) (pay-off phase)
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A T R S C B Z Y X Example of a branched metabolic pathway E 8 E 4 E 1 E 3 E 2 E 7 E 6 E 5 Depending on the context, any or all of the following may be considered a metabolic pathway: A C A T A Z C T C Z *
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glucose pyr R S C B a final product other than pyruvate Y X Glycolysis as a part of a branched metabolic pathway hexokinase * phosphofructokinase (an allosteric enzyme) an allosteric enzyme glucose pyr glycolysis glucose a final product other than pyruvate a different metabolic pathway See textbook Fig. 9.20 (p. 178) 8 r e ac t i o n s
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Phosphofructokinase is an allosteric enzyme Another metabolic pathway Regulation of glycolysis at the enzyme phosphofructokinase glycolysis phase 1 glycolysis phase 2 *
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Some Alternative Possible Fates of the Pyruvate Generated During Glycolysis * glucose 2 ATP glycolysis 2 NADH 2 pyr food fermentation products respiration products - Pyruvate may serve a a food source for making bigger & more complex molecules, using anabolic pathways. - Pyruvate may be reduced by fermentation. - Pyruvate may serves as a fuel by continuing respiration, using catabolic pathways.
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An Example of Pyruvate Used as a Food (Building Material) pyruvate * alanine (an amino acid)
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Fermentation and Glycolysis * The equations for fermentation and glycolysis look similar, except that in fermentation no hydrogen atoms are released (i.e. there is no net oxidation of substrate). Fermentation written as a single equation
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This note was uploaded on 09/28/2008 for the course BIO 311C taught by Professor Satasivian during the Spring '08 term at University of Texas at Austin.

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web_L28_08BIO311C - BIO 311C March 31, 2008 Phase 2 of...

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