Session 5 - Tissue Stem Cells II Neural SC

Session 5 - Tissue Stem Cells II Neural SC - Session V...

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Unformatted text preview: Session V 2-5-07 Tissue Stem Cells II l S C Neural SC During development there is a progressive and generally irreversible lineage restriction of tissue stem cells Gastrulation Gastrulation Nervous tissue Nervous tissue Neuronal stem cells Neuronal stem cells Ectoderm Ectoderm Blastocyst Blastocyst Skin Skin Skin stem cells Skin stem cells Mesoderm Mesoderm Embryonic Embryonic stem cells stem cells Bone marrow and blood Bone marrow and blood Mesenchymal/hematopoietic SCs Mesenchymal/hematopoietic SCs Muscle and bone Muscle and bone Tissue SCs Tissue SCs ung liver pancreas ung liver pancreas Endoderm Endoderm Lung, liver, pancreas Lung, liver, pancreas Organ specific SCs Organ specific SCs Esophagus, stomach, Esophagus, stomach, rimordial germ cells rimordial germ cells intestine/ intestine/ Intestinal SCs Intestinal SCs Adapted from Handbook of Stem Cells Adapted from Handbook of Stem Cells Primordial germ cells Primordial germ cells Hierarchy of cell differentiation in the hair follicle Stem Cell Bulge - uiescent, long- ved quiescent, long lived Transient amplifying cell hair germ and matrix- proliferating, short lived Terminally ifferentiated cells Differentiated outer ot sheath cells Medulla ner layers that contribute to differentiated cells Post-mitotic root sheath cells Inner root sheath cells Inner layers that contribute to hair shaft formation Draw a similar diagram for the epidermis How do tissue stem cells arise during development? Hair follicle and epidermal cell fate are specified early during embryogenesis, but the epithelial SC are isolated from the mature animals Hair cells labeled early in development (shh) contribute to hair growth during the whole life of the animal but: Are SC specified early in development, or tissues form first, and than set aside (or receive from a migratory path) stem cells in their specialized niches? Neural Stem Cells Development and clinical applications Default model of neural induction. Nervous system: neurons and glia Neural tube -> Central nervous systems CNS (brain, spinal cord, and retina of the eye) Neural crest -> Peripheral nervous system ll neurons&glia outside the PNS) (all neurons&glia outside the PNS) ypes of cells in the nervous Types of cells in the nervous system Neurons - functional signal transmitter Glia - Oligodendrocytes (myelin sheath)- Astrocytes-support cells Structure of a neuron Synapse Axon is output signal element Synapse Dendrite is the input signal element lassification of neurons...
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This note was uploaded on 09/28/2008 for the course BIO 4400 taught by Professor Tumbar,td during the Spring '07 term at Cornell University (Engineering School).

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Session 5 - Tissue Stem Cells II Neural SC - Session V...

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