Session 15 - Stem Cell Niche - Session XV The Stem Cell...

Info iconThis preview shows pages 1–9. Sign up to view the full content.

View Full Document Right Arrow Icon
Session XV The Stem Cell Niche
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
The fate of ESCs is dependent on the environment
Background image of page 2
Stem cells self-renew and differentiate Stem cells reside in a protected and specialized “niche” self-renewal Niche cell BM Stem cell slowly cycling tivation ECM activation Local gradient of signaling olecules Early progeny rapidly dividing molecules differentiation Terminally differentiated post-mitotic
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
hat distinguishes stem cells from their What distinguishes stem cells from their early, mitotically active progeny? 1. Stem cells could be intrinsically different - chromatin structure and epigenetic modifications ecific transcription factors - specific transcription factors - special adhesive and migratory capabilities - capable of asymmetric cell division 2. The niche instructs stem cells - growth factors critical for stem cells -organize the ECM and the BM - niche cells protect stem cells from outside world assaults
Background image of page 4
Organization and general concept of the SC niche
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Strategy Identify and label stem cells vs niche cells I. Identify and label stem cells vs niche cells II. Isolate pure populations of cells III. Characterize these cell population . entify factors specific to stem cells relative to IV. Identify factors specific to stem cells relative to progeny- KO . Ablate the SC or the niche cell and follow the outcome - loss of niche cell (postmitotic) -> loss of SC - loss of SC -> loss of tissue; but early progenitor cells can re-enter the niche and acquire SC property; or left over SC divide symmetrically to regenerate the numbers of SCs in the niche
Background image of page 6
ypes of niches Types of niches
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
ypes of stem cell regulation by Types of stem cell regulation by the niche
Background image of page 8
Image of page 9
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 09/28/2008 for the course BIO 4400 taught by Professor Tumbar,td during the Spring '07 term at Cornell University (Engineering School).

Page1 / 37

Session 15 - Stem Cell Niche - Session XV The Stem Cell...

This preview shows document pages 1 - 9. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online