32 Ames Aberson

32 Ames Aberson - CEE 597 Lecture 32 Cancer Chemicals and...

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EE 597 - cture 32 CEE 597 Lecture 32 ancer, Cancer, Chemicals nd and Human Health 13 April 2007 Jery Stedinger Lecture 32 1
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Readings Mon Ames; Abelson, Horomesis; Stolen Futures; teingraber; Steingraber; Wed Big risks-EPA Advisory Panel, Wildsky Morall, Review of the Record Kelman, Benefit-cost analysis Fri AIDS, Hearts and Hulley, “Preventing the heterosexual spreads of AIDS” 13 April 2007 Jery Stedinger Lecture 32 2
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Fewer doctors urge weight loss April 20, 2004 13 April 2007 Jery Stedinger Lecture 32 3
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Some extra heft may be helpful, new study ys says 13 April 2007 Jery Stedinger Lecture 32 4
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Some unexpected findings 13 April 2007 Jery Stedinger Lecture 32 5
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Comic 13 April 2007 Jery Stedinger Lecture 32 6
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Exposing the threat of Dioxin Worldwide 13 April 2007 Jery Stedinger Lecture 32 7
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EPA Report on Dioxins Cancer Risks 13 April 2007 Jery Stedinger Lecture 32 8
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FDA: Natural risks in food outweigh man-made angers dangers 13 April 2007 Jery Stedinger Lecture 32 9
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Trusting to Luck Trusting to Luck 13 April 2007 Jery Stedinger Lecture 32 10
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How Safe is Our Food 13 April 2007 Jery Stedinger Lecture 32 11
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Ames, Magaw, and Gold Ranking Possible Carcinogenic Hazards TD 50 = daily dose in mice or rats at which 50% of animals are tumor ee at end of lifetime [mg/day/kg] free at end of lifetime [mg/day/kg] HERP = Human Exposure/ Rodent Potency dose = Human Exposure/ TD 50 Not a direct measure of human health hazard Danger with analysis o scaling for size of animals or lifetime lengths No scaling for size of animals or lifetime lengths Cancers have different mechanisms and defenses which will cause dose-response curves to have different shapes SHA not regulating EDB for HERP of 140% OSHA not regulating EDB for HERP of 140% but EPA bands at 0.0004% because of concern for leaching to groundwater used as a water supply and concentration in grains. PA upper bound implies 3 cancers/1000 for uses it considered 13 April 2007 Jery Stedinger Lecture 32 12 EPA upper bound implies 3 cancers/1000 for uses it considered (about 1% of US cancers) (pp 275; 277)
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HERP Table of Daily Human Exposure Possible Hazard TD 50 (mg/kg) 13 April 2007 Jery Stedinger Lecture 32 13
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Ames et al. Conclusion • Need a proper perspective void Chemophobia Avoid Chemophobia • Natural compounds need not be benign— Natural selection isn’t a protection i) Cancer occurs late in life after reproductive period Diets have changed ii) Diets have changed iii) Natural compounds cause cancer in animals • Hazard from useful chemicals generally smaller than from many natural foods (peanut butter, beer, wine, mushrooms) 13 April 2007 Jery Stedinger Lecture 32 14
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Ames et al. Conclusion - Serious hazards • Serious hazards tobacco (30% US cancer deaths: lung cancer + heart disease) alcohol (3% US cancer deaths) turated fats (heart disease; colon cancer) saturated fats (heart disease; colon cancer) 30% is overweight [combating cancer] 5% sedentary lifestyle Æ 86% cancer preventable 10% of lung cancer possibly from radon pollution in homes 13 April 2007 Jery Stedinger Lecture 32 15
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This note was uploaded on 09/28/2008 for the course CEE 5970 taught by Professor Stedinger during the Spring '07 term at Cornell.

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32 Ames Aberson - CEE 597 Lecture 32 Cancer Chemicals and...

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