Session 02 - Embryonic Stem Cells

Session 02 - Embryonic Stem Cells - Session II: EMBRYONIC...

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Session II: MBRYONIC STEM CELLS EMBRYONIC STEM CELLS
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oints from last lecture Points from last lecture eview of: Review of: • Definition of stem cells lasses of stem cells (by 2 criteria) Classes of stem cells (by 2 criteria) • Origin of ESCs & their potential
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Movie sea urchin
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ESC can be considerent totipotent, even though they indirectly give rise to some extraembryonic tissues (through germline formation) Cell therapy
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A slide outlining the purposes of introducing human IVF. Notice that ethics were tressed. This slide, made on an electric typewriter in the early 1980s, was a copy of an stressed. This slide, made on an electric typewriter in the early 1980s, was a copy of an earlier slide used as an opener in many conferences from the early 1970s .
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In vitro fertilization (IVF) Poor quality egg High quality egg Normal fertilized egg Triploid fertilized egg Sperm injection
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Embryo culturing for IVF ay blastocyst stage Normal fertilized egg 5-day blastocyst stage 3-day 8-cell stage/grade 4 Grade 3 Grade 0
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Embryonic Stem Cell Lines Derived from Human Blastocysts James A. Thomson,* Joseph Itskovitz-Eldor, Sander S. Shapiro, Michelle A. Waknitz, Jennifer J. Swiergiel, Vivienne S. Marshall, Jeffrey M. Jones Human blastocyst-derived, pluripotent cell lines are described that have normal karyotypes, express high levels of telomerase activity, and express cell surface markers that characterize primate embryonic stem cells but do not characterize other early lineages. After undifferentiated proliferation in vitro for 4 to 5 yg p months, these cells still maintained the developmental potential to form trophoblast and derivatives of all three embryonic germ layers, including gut epithelium (endoderm); cartilage, bone, smooth muscle, and striated muscle esoderm); and neural epithelium embryonic ganglia and stratified squamous (mesoderm); and neural epithelium, embryonic ganglia, and stratified squamous epithelium (ectoderm). These cell lines should be useful in human developmental biology, drug discovery, and transplantation medicine.
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This note was uploaded on 09/28/2008 for the course BIO 4400 taught by Professor Tumbar,td during the Spring '07 term at Cornell University (Engineering School).

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Session 02 - Embryonic Stem Cells - Session II: EMBRYONIC...

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