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Problem Set 5 - a 4 The authors mention several mechanisms...

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Problem Set 5 Identification of the haematopietic stem cell niche and control of the niche size. 1. What is the goal of the paper? a. 2. How did they block the BMP signal in vivo? How did they analyze the HSC population and what results they obtained/ a. 3. What experiments were done to show that the LT-HSCs population was expanded in the Bmpr1a mutant mice ? What were their results?
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Unformatted text preview: a. 4. The authors mention several mechanisms that can lead to changes in HSCs. Mention them. a. 5. Why did the authors generate a mouse line bearing the Mx1-Cre BMPR1a and Z/ EG alleles? a. 6. Based on the results of this paper, where is the HSC niche located? a....
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