week_12_plasticity_3 - HD 220 2006 1 Temple, 2006 1 How Do...

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Unformatted text preview: HD 220 2006 1 Temple, 2006 1 How Do We Learn? Plasticity and the Brain Week 12, lecture 2 Temple, 2006 2 Plasticity and the Brain Plasticity and changes to the synapse Increase number of synapses Experience Injuries Hormones Neurotrophic factors Increase strength of synapses LTP Plasticity and the effects of experience Critical periods of plasticity Plasticity and the response to training Plasticity and the response to injury Temple, 2006 3 Synaptic Changes Learning and memory Can be increases in number of synapses Modify existing circuits Create novel circuits Add new neurons Can be increases in strength of synapses As discussed earlier LTP, etc Can be both HD 220 2006 2 Temple, 2006 4 Dendritic Changes Dendrites in general Are very dynamic Change shape and orientation Not static Temple, 2006 5 Changes in Dendritic Morphology Temple, 2006 6 Experience and Brain development HD 220 2006 3 Temple, 2006 7 Enriched Experience Enriched experience Changes many aspects of brain structure and morphology of synapses Temple, 2006 8 Synaptic Changes Changes in number of synapses Can increase OR decrease Decreases can be positive Sculpting process Gets rid of unnecessary synapses Decreases can be negative Abnormal development or disease Temple, 2006 9 Injury and Abnormal Development HD 220 2006 4 Temple, 2006 10 Hormones & Plasticity Hormones Powerful abilities to change neurons and pattern nervous system Often change genes that are expressed in cells to make dramatic changes in cell Can affect number of synapses and dendrite morphology Examples: Gonadal hormones Produced by gonads Estrogen Testosterone Glucocorticoids Stress hormones Cortisol Temple, 2006 11 Neurotrophic Factors Neurotrophic factors Compounds that promote the growth and survival of neurons Produced in brain By neurons and glia...
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week_12_plasticity_3 - HD 220 2006 1 Temple, 2006 1 How Do...

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