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week_4_neurons_are_chemical_1_3

week_4_neurons_are_chemical_1_3 - Neurons are Chemical The...

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HD 220 Fall 2006 1 Temple, 2006 1 Neurons are Chemical: The Synapse & Neurotransmitters Week 4, Lecture 1 Temple, 2006 2 Neurons are Chemical • Synapse Stages of Chemical Communication • Neurotransmitters • Receptors Temple, 2006 4 Loewi’s Experiment
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HD 220 Fall 2006 2 Temple, 2006 5 Neuronal Signaling Electrical Signaling Chemical Signaling at the synapse Electrical signal transfers info WITHIN a neuron Chemical signal transfers info BETWEEN neurons Temple, 2006 7 Synapse Temple, 2006 8 Synapse http://www.itg.uiuc.edu/exhibits/gallery/
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HD 220 Fall 2006 3 Temple, 2006 9 Synapses http://synapses.bu.edu/anatomy/index.stm http://keck.ucsf.edu/classes/physio126/EM-neuronal-components.html Temple, 2006 10 Synapse Types Temple, 2006 11 Dendrodendritic Synapse http://synapses.bu.edu
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HD 220 Fall 2006 4 Temple, 2006 12 Synapse Types Temple, 2006 13 Type 1 & 2 Synapses Type 1 Type 2 http://synapses.bu.edu Temple, 2006 14 Neurons are Chemical • Synapse Stages of Chemical Communication • Neurotransmitters • Receptors
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HD 220 Fall 2006 5 Temple, 2006 15 Stages of Chemical Communication 1. Synthesis: a) Chemicals (neurotransmitters) must be synthesized and stored 2. Release from presynaptic cell a) Neurotransmitter must be transported and released 3. Receptor action on postsynaptic cell a) Neurotransmitter must get to receptor on target cell and bind 4. Inactivation a) Neurotransmitter must be inactivated and recycled Temple, 2006 16 Synthesis Neurotransmitters are made – In the axon terminal or – In the soma & transported to axon terminal
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