BMB 402 LECTURE NOTES 9-23-08 - START OF MATERIAL FOR EXAM...

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START OF MATERIAL FOR EXAM 2 BMB 402 general biochemistry 2 Lecture 9-23-08 Presentation-glucose versus fructose Yellow Number Five Causes Behavioral Changes metabolism is regulated such that a change in one part of the meshwork does not cause  a significant change/distortion in the rest of the system GLYCOGEN serves to reduce the osmotic pressure made of 50,000 glucose molecules molecular weight is equal to 10 million 21 nm diameter 2000 non-reducing ends highly branched structure (fast to degrade to glucose monomers) 12 tiers liver cells have up to 10% glycogen muscles have 1 - 2% glycogen REMOVAL OF GLUCOSE FROM A GLYCOGEN CHAIN Enzyme - Glycogen Phosphorylase  Enzyme Activity - removes glucose residues until it gets to the fourth glucose unit  from the branching point. When a glucose residue is cleaved off the end of a  glycogen chain the energy stored in the bond is used to add a phosphate onto the  free glucose molecule. The result is that glucose is released in the form of glucose-1- phosphate (more energy) and the chains still ends with a reducing end.   Enzyme - Bifunctional De-Branching Enzyme Enzyme Activity 1 (transferase activity) - after glycogen phosphorylase reduces a  glycogen chain to the fourth glucose unit the de-branching enzyme moves the last 3 
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This note was uploaded on 09/28/2008 for the course BMB 402 taught by Professor Krasilnikov during the Fall '08 term at Pennsylvania State University, University Park.

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BMB 402 LECTURE NOTES 9-23-08 - START OF MATERIAL FOR EXAM...

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