BMBPractice_exam_III-08

BMBPractice_exam_III-08 - BMB 401Summer 2008 Practice Exam...

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BMB 401Summer 2008 Practice Exam 3 Page 1 1) Hexokinase catalyzes the first committed step in glycolysis. T F 2) The total free energy change for each glycolytic reaction under standard conditions is different than the total free energy change of the same reaction under intracellular conditions? Why? a. this difference is brought about by decreases in the product/reactant ratio b. this difference is a result of catalysis by the efficient enzymes in this pathway c. this difference is brought about by increases in the product/reactant ratio d. these answers are all wrong 3) Enzyme “B” is positively regulated by phosphorylation at a site (residue) other than the active site. What could you hypothesize to be true? a. Phosphate addition requires that a serine, threonine or tyrosine residue be present in enzyme B in the proper context. b. Phosphate is most probably acting as a competitive inhibitor c. Addition of the phosphate has an allosteric effect on the enzyme d. All the above are true e. All but b are true f. All but c are true 4) Enzyme “B” is positively regulated by phosphorylation at a site (residue) other than the active site. The normal phosphorylation site has been mutated as indicated below. Which of the following scenarios could you hypothesize to be true? a. Replacement of the normal phosphorylation site by an alanine would prevent inhibition by phosphorylation. b. Replacement of the normal phosphorylation site by an alanine would prevent normal activation by phosphorylation c. Replacement of the normal phosphorylation site by an aspartate could cause the enzyme to be activated essentially at all times d. All the above are true e. All but b are true f. All but a are true 5) Protein kinase A (PKA) is activated by the binding of cyclic AMP to the PKA catalytic domains, allowing release and thus activation, of the catalytic domains. T F 6) Protein kinase A regulates the activities of target proteins by phosphorylating particular serine and threonine residues in regulatory regions of the target proteins. T F 1
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This note was uploaded on 09/28/2008 for the course PHY 183 taught by Professor Wolf during the Summer '08 term at Michigan State University.

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BMBPractice_exam_III-08 - BMB 401Summer 2008 Practice Exam...

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