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BMBN_5B_study_aid_key - BMB 401Summer 2007 EXAM 5 study aid...

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BMB 401Summer 2007 EXAM 5 study aid for the final Page 1 1.Which of these is implicated in the recessive, fatal, neurodegenerative, Tay-Sachs disorder? a. Defect in or absence of the enzyme ( β -N-acetylhexosaminidase) which facilitates break down of gangliosides b. Defect in synthesis of gangliosides c. Defect in the synthesis of dipalmitoyl-phosphatidyl choline d. Defect in an enzyme (prenyl transferase) which is necessary for the synthesis of cholesterol 2.How are sugars usually activated in the synthesis of phospholipid head groups? They are: a. CDP-linked b. Carboxylated c. CoA-linked d. UDP-linked 3.Which is NOT a use of phosphatidic acid in cells? a. Phosphatidic acid is activated to produce squalene during cholesterol biosynthesis. b. Phosphatidic acid is activated by CTP during phospholipid synthesis. c. Phosphatidic acid is dephosphorylated and receives an activated fatty acid to form triacylglycerol. d. Phosphatidic acid is dephosphorylated to diacylglycerol and receives an activated alcohol head group to form a phospholipids e. Phosphatidic acid is an important precursor in the synthesis of uric acid 4.Fatty acids are activated before addition to glycerol or dihydroxyacetone phosphate (DHAP) a. Through a Thiol-ester linkage to CoA b. Through ester linkage with UDP c. Through phosphorylation d. All the above are used 5.Which reaction below is the regulated step in cholesterol synthesis? a. acetoacetyl-CoA + acetyl CoA + H 2 O > HMG-CoA + CoA b. HMG-CoA + 2H + + 2NADPH > Mevalonate + 2NADP + + CoA c. HMG-CoA + acetyl CoA > Squalene + CoA d. 2 acetyl-CoA > acetoacetyl-CoA 6.Please put these synthetic reactions in order: a. 1, II, 1V, V, III b. 1V, 1, II, V, III c. 1, 1V, III, II, V d. 1V, V, II, I, III e. 1, II, III, 1V, V I. Formation of Squalene II. Formation of Farnesyl pyrophosphate III. Cyclization to Lanosterol IV. Formation of 3-Isopentyl pyrophosphate V. Formation of Geranyl pyrophosphate
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BMB 401Summer 2007 EXAM 5 study aid for the final Page 2 7. HMG reductase is phosphorylated in response to what signal, and how does this Phosphorylation affect the activity of the enzyme? a. Phosphorylation by AMP-activated kinase decreases this enzyme’s activity b. Phosphorylation by AMP-activated kinase increases this enzyme’s activity c. Substrate level phosphorylation decreases this enzyme’s activity d. Substrate level phosphorylation increases this enzyme’s activity 8.Synthesis of NH 4 + from N 2 happens in our mitochondria as part of the urea cycle. F 9.Symbiotic bacteria rely on leghemoglobin to increase their O 2 concentration. F 10. In low NH 3 concentration, NH 3 assimilation relies on glutamine synthetase. T 11. What are statins? a. Drugs that bid bile salts ad prevent their re-absorption by the liver
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BMBN_5B_study_aid_key - BMB 401Summer 2007 EXAM 5 study aid...

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