LAXATIVES & CATHARTICS - LAXATIVES and CATHARTICS = AGENT FOR TX OF CONSTIPATION Laxatives are agents that cause the formation of Soft Formed but

LAXATIVES & CATHARTICS - LAXATIVES and CATHARTICS =...

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LAXATIVES and CATHARTICS = AGENT FOR TX OF CONSTIPATION Laxatives are agents that cause the formation of Soft Formed, but not watery, stool . Cathartics (or Purgatives) are agents that form fluid (watery) stool or incompletely formed stool . GROUP EXAMPLES MECH. OF ACTION B ulk Laxatives or Fibre laxatives Psyllium (natural fibre) Bran, Methyl cellulose (Semin-synthetic fibre) Polycarbophil (Synthetic fibre) NB : Fibre is a form of “sugar”, undigestible sugar - Are i nsoluble and non-absorbable - Contain a lot of fiber that absorb water in the bowel and expand as it does so, without dissolving - => increase in bowel content => triggers stretch receptors in the intestinal wall => causes reflex contraction (peristalsis) that propels the bowel content forward, & shortening intestinal trasnsit time O smotic Laxatives Salts (or Saline Cathartics) : Mg- Citrate, Mg(OH) 2 (milk of magnesia), MgSO 4 , Na 2 PO 4 , Sugar: Sorbitol and lactulose, Polyethylene glycol (PEG), mannitol - Are partially soluble , but not absorbable - Are VERY concentrated product -
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  • Spring '17
  • DR SHITTU
  • Receptor antagonist, Laxative, incompletely formed stool, Soft Formed

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