Analgesics, Antipyretic & Anti-inflammatory Drugs - ANALGESIC-ANTIPYRETIC ANTI-INFLAMMATORY AGENTS OBJECTIVES 1 2 3 4 Definitions\/Understanding of

Analgesics, Antipyretic & Anti-inflammatory Drugs -...

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Page 1 ANALGESIC-ANTIPYRETIC & ANTI-INFLAMMATORY AGENTS OBJECTIVES 1. Definitions/Understanding of terms 2. Cause/mechanism Pain, Fever and Inflammation 3. Mechanism of Action of NSAIDs, & Aspirin 4. Pharmacology of NSAIDs SOME TERMS TO UNDERSTAND 1. Pyrexia (Fever): increase in body temp. above normal (37ºC) 2. An Antipyretic is an agent that reduce fever or prevent induction of fever 3. Stimuli for fever: Infection, Exercise (NB: Antipyretics cannot reduce exercise-induced pyrexia), etc. 4. Inflammation: Response of the body to injurious stimuli (Physical, chemical, Biological, etc.) characterized by vasodilation, increased vasc. permeability, edema (swelling), immune cell infiltration into tissues, Pain (dolor), tissue destruction, etc… Inflammatory responses are protective. Unfortunately, it also causes pain and, in a chronic condition, tissue damage (such as that seen in rheumatoid arthritis) . 5. Inducers of inflammation may include: Increased reactive O 2 spp, unfolded protein, etc 6. Analgesics drugs used to reduce pain 7. Pain: Pain is part of inflammatory response caused by pain signals emanating from pain nerves from spinal or supra-spinal levels 8. NSAIDs = Non-steroidal anti-inflammatory drugs are antipyretic, anti-inflammatory and analgesic agents. Since these drugs are named ‘Non - steroidal’, it means that Steroidal anti -inflammatory drugs i.e. Glucocorticoids 9. However, Aspirin has antipyretic, anti-inflammatory and analgesic properties BUT is NOT an NSAID (because its chemical structure is very different from that of other NSAIDs); still, it is discussed along with NSAIDs …….[Lecturer] 10. In addition, Acetaminophen (paracetamol) is a drug with Antipyretic, Analgesic, BUT NOT anti- inflammatory activities, @ therapeutic dose . Hence, it is not an NSAID MECH. OF PYREXIA, PAIN AND INFLAMMATION A. Link between Pyrexia, Pain and Inflammation a. Injurious Factors Inflammation Pain stimulation (Hyperalgesia) + Pyrexia (Fever). The work of NSAIDs is to inhibit inflammation B. Physiology, Molecular & Biochemical Biology involving inflammation a. Cellular damage causes release of DAMPs (Damage-associated membrane patterns) which activate a no. of mech. that cause inflammation b. PAMPs (Pathogen-associated Molecular Patterns) are foreign polysaccharides recognized by receptors (e.g. Toll-like receptors) of cells of the innate immune system in the body.
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  • Spring '17
  • Paracetamol, Cyclooxygenase

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