Anti-Asthmatic Drugs - ANTI-ASTHMA DRUG DRUGS USED IN ASTHMA Asthma is a chronic inflammatory disease characterized by airway inflammation and episodic

Anti-Asthmatic Drugs - ANTI-ASTHMA DRUG DRUGS USED IN...

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Page1 Page1 ANTI-ASTHMA DRUG - DRUGS USED IN ASTHMA Asthma is a chronic inflammatory disease characterized by airway inflammation and episodic, reversible bronchospasm. The asthmatic response to inhaled allergens takes place in two phases: The immediate responseis the early, acute phase reactionin which the allergen, upon binding with IgE on mast cellsand basophils, triggers degranulation of these cells with the release of histamine, and leukotrienes (LTs). These mediators cause smooth muscle contraction and bronchial constriction which are manifested by a shortness of breath, wheezing, and coughing (= Acute Episodes), that can besevere and life-threatening.The late phase reactionoccurs several hoursafterthe initialreactionand is characterized by excessive inflammation, infiltration of the airway by eosinophilsand other cytokine-secreting leukocytes, and structural changes that lead to airway remodeling (thickening of the airway wall). So, the drugs useful in asthmatxgenerally include those that treat early phase (or acute episodes)of asthmatic attack (bronchodilators or smooth muscle relaxants) and those that prevent both acute and late phaseof asthmatic (anti-inflammatory drugs and leukotriene antagonist. CLASS EXAMPLES COMMENTS BRONCHODILATORSor “Reliever” drugs= used to treat early or acute episodes(bronchoconstriction); are generally short-acting (except long-acting β2-receptor agonists) a.β2-selective adrenoceptor agonists Short-acting(4hrs or less) = Albuterol, Terbutaline, Metoproterenol, salbutamol Long-acting(12hrs or less) = Salmeterol, Formoterol Activate Adenyly cyclase (AC), the enz. that converts ATP to cAMP => generally inhibits
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  • Spring '17
  • DR SHITTU
  • allergic asthma

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