ANTI-Anemic drugs - ANTI-ANEMIC DRUGS OUTLINE 1 Introduction a Hemopoiesis b Anemia 2 Anti-anemic drugs INTRODUCTION Hemopoiesis is the formation of RBC


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Page 1 ANTI-ANEMIC DRUGS OUTLINE 1. Introduction a. Hemopoiesis b. Anemia 2. Anti-anemic drugs INTRODUCTION Hemopoiesis is the formation of RBC, Platelets, and WBCs, from diff stem cells a. Site: Bone marrow in Adults b. Nutrient requirements: Iron, Vitamin B12, Folic acid and Hemopoietic growth factors a. Iron : i. Total iron in the body = 4 to 5g, of which 65-70% is in the form of Hb, 1% in various heme cpd & 15-30% in the form of Ferritin & Hemosiderin ii. Fe is required for Hb production. In the absence of adequate of Fe Microcytes with insufficient Hb are formed (Microcytic Hypochromic anemia) b. Vitamin & Folic acid i. Required for Normal DNA synthesis. Their deficiency results in impaired prodxn and abnormal inactivation of RBC - Macrocytic anemia or Megaloblastic anemia c. Erythropoietin and Colony-stimulating Factors (CSF) are hormones that regulate blood cells with respect to their development and proliferation in the B.M. They mostly used in Cancer Chemotherapy Anemia a. It is a clinical condition caused by an acquired or hereditary abnormality of the RBC (i.e. caused by hemolytic conditions) or it may be a manifestation of the underlying non-hematologic conditions b. Signs and Symptoms a. for Pxs with Hb < 7g/dl, they will have symptoms of tissue anemia = Fatigue, pallor, Angina, Tachycardia, headaches, etc. c. Classification a. Anemia associated with decrease in RBC production. E.g. IDA, Megaloblastic anemia, Thalassemia, ACD, Renal failure b. Anemia due to increase RBC destruction. E.g. Hemolytic anemia (sickle cell Pxs) ANTI-ANEMIC DRUGS 1. IRON Preparations a. Oral iron: Ferrous sulphate, Ferrous gluconate, Ferrous fumarate b. Parenteral Iron: Iron dextran, Iron sucrose, Na-Ferric-Gluconate complex 2. VITAMINS a. Vitamin B12 b. Folic acid (Vit. B9) 3. Hemopoietic GF a. Erythropoietin (Epoetin- α, Darbepoietin - α, Methoxypolyethylene, Glycol -epoietin- β)
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Page 2 IRON Oral Iron 1. Absorption: Fe 2+ is absorbed from the duodenum & upper jejunum; Fe 3+ absorption is from Intestinal Mucosal cells 2. Distribution: Fe 2+ bind Transferrin in plasma and is transported to other tissue, where they are stored as ferritin (and as Hemosiderin). This Iron-Transferritin complex bind with receptors on developing RBCs in the B.M., providing an efficient mech. for incorporating Fe into Hb in developing cells 3. Storage: The Ferritin and Hemosiderin are stored in mucosal cells, liver, spleen and B.M.
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  • Spring '17
  • Folic acid, Vitamin B12, Megaloblastic Anemia

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