Exam2Lectures - 2008-09-25 Cancer What Is Cancer? Cancer is...

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19:02 Cancer What Is Cancer? Cancer is unrestrained cell proliferation caused by damage to genes regulating cell division. -Control of the cell cycle Fig 9.10   Movie Cancer cells: tumor Fig. 9.12 metastasize Fig. 9.13 Benign and malignant  tumors 1) the cell multiplies continuously and/or at a higher than normal rate o benign or noncancerous o encapsulated 2) metastasis Movie o cancerous o malignant Proto-oncogenes / Oncogenes
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Proto-oncogenes     o normally perform essential functions "turning on" other genes controlling cell growth and development inhibit growth of cancer cells tumor suppressor genes Fig. 9.14  Movie  Image Movie2 Proto-oncogenes     o oncogenes ("cancer genes"). o oncologists. Processes that change proto-oncogenes to oncogenes  (transformation) may include: Image  Image2 1 Simple mutations of the proto-oncogene ---> now makes proteins with altered structure and function 2 Simple mutations of nearby genes but not within the proto-oncogene ---> protein not altered, but may synthesize too much, too little or at the wrong  time 3. Amplification o A lot more protein is made than should be can be caused by having multiple copies of the 
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This note was uploaded on 09/30/2008 for the course BIO 49935 taught by Professor Jasper during the Spring '08 term at University of Texas at Austin.

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Exam2Lectures - 2008-09-25 Cancer What Is Cancer? Cancer is...

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