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Lecture8Spr08

Lecture8Spr08 - *Essay Read instructions on web Read...

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Unformatted text preview: *Essay : Read instructions on web. Read examples of “bad sentences” (from previous 432 essays) -- will be put into the same folder by tomorrow. Figure out what’s wrong with the writing. Explanations will be posted on the weekend. Animation on microtubules : nogales_400x300_narrated.mov Bending of cilia caused by action of axonemal dynein *Transport takes place in both directions. Cooperation of kinesin and cytoplasmic dynein Cooperation of kinesin and cytoplasmic dynein Cooperation of kinesin and myosin at cell cortex Old Fig 20-24 *Transport can take place both on microtubules (kinesin and dynein motors) and on microFlaments (myosin motors). Changes in microtubule array during mitosis *Dual fuorescence: DNA blue, MTs green MTOCs Changes in microtubule array during mitosis Changes in microtubule array during mitosis Fig 18.36a *Hi voltage EM (because specimen thick) Videos: 1806_mitosis.mov 1806_tubulin.mov Animation: 1806_mitosis.swf Fig 18.36b Mitotic spindle apparatus *There are three kinds of spindle microtubules. All grow from (have minus end in) the centrosome (= MTOC = spindle pole body):-Kinetochore MTs: are ‘captured by’ (attach to) chromosomes.-Polar MTs: interdigitate antiparallel at middle of spindle.-Astral MTs: radiate out into cell away from spindle. *Mammalian MTs at mitosis are especially dynamic (half life of ~1 min, compared with ~10 min at interphase. Increase in “dynamicity ”. Attachment of MTs to kinetochores * “Centromere ” and “centromeric chromatin” refer to the DNA sequences and attached proteins that deFne at the DNA level where chromosomes will become attached to the spindle. * “Kinetochore ” refers to the protein structure at the point of attachment of the spindle microtubules....
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Lecture8Spr08 - *Essay Read instructions on web Read...

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