Lecture7Spr08 - Informational advertisement: The Bioethics...

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Unformatted text preview: Informational advertisement: The Bioethics Society of Cornell Are you interested in the infuences that shape the way society views biology and its applications? Come to the next meeting oF the Bioethics Society oF Cornell! BSC encourages discussion oF controversial topics in liFe sciences and its related applications, through group discussions and guest speakers in elds that are aFFected by bioethics. Learn how distinct elds such as biology, law, religion, research, sociology, history, medicine and many more become highly integrated when examining the morality oF key controversial issues in today's society From stem cell research to euthanasia to tissue transplantation to animal dissection in high schools! Learn about the many Factors that infuence the way liFe sciences and related applications are viewed by individuals and a society as a whole! The BSC meets Mondays at 4:45pm in 119 Stimson *See instructions for Paper 1 on course web site, in the assignments folder. Read it carefully! *Papers are due Friday Feb 22 (up to 4 pm in box by VMV ofce #358 or in MBG ofce on ground oor of Biotech. *Late papers : Monday = 1/3 grade drop; every day thereafter another 1/3 grade drop. *Later this week some examples of badly written sentences and paragraphs will be posted on Blackboard. Look at each one and gure out whats wrong with it. *Quiz this Wednesday, 8:40 - 8:55 . Covers Lectures 4 - 7. Same format as last time. All quizzes collected at 8:55. Fig 17.27 Myosin step size *Can use optical tweezers (see Fig. 17.26) to measure force generated by one myosin molecule, as well as the size of the step that it moves. *Myosin II doesnt stay bound to the lament, but rather falls off and rebinds continuously. Step size around 15 nm. *By contrast, Myosin V is very processive : stays bound most of the time and walking along actin lament without falling off. *For myosin V, measured step size is 36nm. Myosin step size *Two possible models for myosin stepping: (a) hand-over-hand, and (b) inchworm. * Experiment : Label only one of the two myosin heads with a Fuorescent tag. *Watch the Fuorescent spot move on - actin and plot results. * Which model appears to be correct? *How is this experiment possible since the step size is much smaller than the wavelength of light? Fig 17.28 Microtubules *MTs in green. *Chromosomes (DNA stain) in blue. *Intermediate flaments (keratin) in red. Microtubule organizing center (MTOC) High resolution EM of two microtubules Negative stain EM Old Fig Subunits of a microtubule *Two related proteins, alpha- and beta-tubulin, found in all eukaryotes....
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Lecture7Spr08 - Informational advertisement: The Bioethics...

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