Lecture6Spr08 - First essay Get info from assignment sheet...

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Unformatted text preview: First essay Get info from assignment sheet in Assignments Folder on the web site. Read this carefully! Will be available on web site by Saturday morning. Read the short review article. Will be available on web site by Saturday morning. Write essay and in it answer the questions posed in the assignment sheet. Maximum length is 1000 words of text (gures and references dont count). Submit BOTH a hard copy AND on the course website in drop off box an identical electronic copy with the word count printed at top . Do NOT put your name on the hard copy , but only your made up PIN as an ID. Follow directions on assignment sheet for naming the electronic copy. Due : Friday Feb. 22 by 4pm (after class, in box by VMV ofce 358 Biotech, or to VMV or KH personally). (Note that the Biotech Bldg is locked at ~4:30pm on Fridays!) Penalty for late papers will be announced. Abstract : "The budding yeast has been a useful model for dissecting the mechanisms a cell uses to establish and utilize a polarized actin cytoskeleton. By using the process of bud growth as a measure of cell polarity, we have Feshed out the molecular pathway for how this occurs in yeast. In response to signals generated by RhoGTPases at the plasma membrane, formin family proteins together with prolin nucleate actin laments that grow into cables stretching through the yeast cell. Myosin-V motors then migrate along these laments, leading to a polarization of membranes and proteins needed for bud growth." Enrichment lecture this riday *Dave Pruyne (research associate in Bretscher lab) will talk on Figuring out the molecular mechanisms of actin-dependent polarization of the cell"- 245 Warren, 9:05 - 9:55. Movie: macrophage crawling (old text) v19-04-macrophage.mov Movie: chemotaxis (Dictyostelium crawling toward cyclic AMP) 1707_chemotaxis.mov Review : Mechanism of movement: keratinocyte example Fig. 17.38 *Focal adhesions = topic of later lecture. * Know the terms in boxes. Animation: how a cell crawls a19-04-cell_motility.swf (same as Fig. 17.38) Fig. 17.15 *Arp proteins are related in sequence to actin (~50% AA identity). *The Arp2/3 protein complex can bind to the side of an actin Flament and nucleate growth of a new Flament. *This picture shows the leading edge of a cell, where rapid polymerization occurs to form a gel that pushes the cell membrane forwards. Review : Actin polymerization at the leading edge of a migrating cell Fig. 17.17 *This bacterium propels itself in the infected cell cytoplasm by generating a tail (or cloud or comet) of polymerized actin at one end....
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Lecture6Spr08 - First essay Get info from assignment sheet...

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