Lecture6 - blackboard.sunysb.edu BIO328 Mammalian...

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Unformatted text preview: blackboard.sunysb.edu BIO328 Mammalian Physiology Synaptic Transmission 2 Synaptic Transmission 1. Action potential travels down axon and invades nerve terminal causing a depolarization 2. Depolarization opens voltage-gated Ca 2+ channels 3. Influx of Ca 2+ ions into nerve terminal raises Ca 2+ concentration 4. Increased Ca 2+ concentration promotes fusion of synaptic vesicles with cell membrane 5. Release of neurotransmitter into synaptic cleft 6. Neurotransmitter binds to neurotransmitter receptor on post-synaptic cell causing channels to open 7. Ion flow through channels changes membrane potential, possibly triggering an action potential 8. Neurotransmitter unbinding and removal exocytosis synaptic delay Intracellular and Extracellular Fluids Internal External (in mM) K + 125 5 Na + 12 120 Cl- 5 125 Ca 2+ 1 x 10-4 (100 nM) 2 A- 108 A- = proteins, amino acids (aspartate and glutamate), inorganic ions (sulfate and phosphate), nucleotides, DNA, RNA Ca 2+ binding proteins Na-Ca exchanger acetylcholine (ACh) excitatory Neuromuscular Junction (NMJ) Exocytosis freeze-fracture electronmicrograph thin section electronmicrograph Exocytosis exocytosis synaptic delay Synaptic Transmission 1. Action potential travels down axon and invades nerve terminal causing a depolarization 2. Depolarization opens voltage-gated Ca...
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Lecture6 - blackboard.sunysb.edu BIO328 Mammalian...

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