Lecture2 - BIO328 Mammalian Physiology...

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blackboard.sunysb.edu BIO328 Mammalian Physiology
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Lecture 2 Basic Cellular Physiology and Ion Channels
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Polar and charged molecules cross the cell membrane using membrane proteins Pumps - require energy in the form of ATP to move ions up concentration gradients Ion channels - facilitate diffusion of ions by creating pores in the cell membrane Transporters - do not directly require metabolic energy, often linked to ion gradients that indirectly provide the energy
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Transporters Facilitated Diffusion Secondary Active Transport require energy in the form of ion gradients
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Hydrophobic molecules
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Facilitated Diffusion passive glucose transporter
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Ion Gradients as Sources of Cellular Energy Source of chemical energy e.g. secondary active transport Source of electrical energy membrane potential
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Na-Glucose symporter
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LacY (lactose permease)
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V 6-16 neurotransmitters
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Regulation of Internal Ca 2+ Ion Concentration Intracellular Extracellular (in mM) K + 125 5 Na + 12 120 Cl -
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Lecture2 - BIO328 Mammalian Physiology...

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