Lecture3 - Textbook Molecular and Cellular Physiology of...

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blackboard.sunysb.edu Textbook Molecular and Cellular Physiology of Electrically Excitable Cells - David McKinnon
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Lecture 3 Membrane Potential brain and muscle function are electrochemical phenomena Bioelectricity voltages in cells are generally less than 100 mV (millivolts) currents are in the range of nA (nanoamps)
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Ions move through solution by diffusion water molecules, 75% of total body weight and 99% total number of molecules pure water, a poor conductor of electricity
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polar molecule polar covalent bonds electronegativity dipole
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Because of its polar nature water is an excellent solvent for salts, acids and bases salts, acids, bases, dissociate into ions in water Na + and Cl - NaCl table salt uncharged, cannot carry a current
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ionic bonds
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electrostatic solvation
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dissociated ions are the primary electrical current carriers in the body Electrolytes cations - positive charge anions - negative charge
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hydration shell
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Electric current in aqueous solutions
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Ohm’s Law I = V / R
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Intracellular and Extracellular Fluids Intracellular Extracellular (in mM) K + 125 5 Na + 12 120 Cl - 5 125 Ca 2+ 1 x10 -4 (100 nM) 2 A - 108 0 A - = the fixed anions, sum of all the proteins, amino acids, inorganic ions, nucleotides, DNA, RNA that are located inside the cell.
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Cell Membrane
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Cell Membrane barrier to diffusion lipid bilayers phospholipids
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Phospholipids two distinct regions polar - hydrophilic, interact with water molecules nonpolar - hydrophobic, interacts with other hydrophobic molecules amphipathic
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Lipid Bilayer hydrophobic core like thin layer of oil
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fluid mosaic model integral membrane proteins
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amphipathic Integral membrane proteins
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membrane 60Å (6 nm) thick hydrophobic core 30Å (3 nm) thick
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peripheral membrane proteins cytoskeletal glycoproteins
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Hydrophobic molecules diffuse through the lipid bilayer lipophilic (hydrophobic) molecules cross the cell membrane by simple diffusion solute can dissolve into lipid membrane oxygen, carbon dioxide, fatty acids, steroid hormones
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Lecture3 - Textbook Molecular and Cellular Physiology of...

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