Lecture7 - Intrinsic Electrophysiological Properties of...

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Intrinsic Electrophysiological Properties of Neurons
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Schemes for classification of voltage gated ion channels ion selectivity kinetic properties threshold for activation subcellular location pharmacology gene family
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Classification based on ion selectivity Na + K + Ca 2+ Cl - cation (Na + and K + ) excitatory inhibitory excitatory inhibitory excitatory
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Classification based on kinetics
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Closed v. fast fast v. slow slow Open Inactivated At Vm = -80 mV v. fast Closed Open Inactivated At Vm = +10 mV activatio n deactivation inactivation inactivation Kinetic Properties of Voltage-Gated Channels voltage-dependent rate constants
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Rapidly activating: Na + channel - I Na K + channel - I A (A-type K + channel) Non-inactivating: - Na + channel – I Na,P (persistent Na + channel) - K + channel - I M (M-type K + channel)
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1.0 0.5 -120 -80 -40 0 40 threshold resting membrane potential high threshold low threshold Classification based on threshold for activation I Na I K - delayed rectifier I C - large Ca 2+ activated K + channel
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1.0 0.5 -120 -80 -40 0 40 threshold resting
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Lecture7 - Intrinsic Electrophysiological Properties of...

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