Damage and disorders - Slide 1 Disorders and Damage •...

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Unformatted text preview: Slide 1 Disorders and Damage • Degenerative disorders – Parkinson’s disease – Alzheimer’s disease • Neurological damage – Stroke • Developmental disorders – Autism • Psychological disorders – Schizophrenia ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ Slide 2 Parkinson’s disease • Major degenerative disease resulting from degeneration of dopamine-producing neurons in the substantia nigra – Nigrostriatal system ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ Slide 3 Parkinson’s disease symptoms • Symptoms are primarily motor deficits – Muscular rigidity – Slowness of movement – Resting tremor – Postural instability • Cognitive deficits appear in late stages of PD – Speech is impaired – Dementia is seen in late stages of PD in ~25% of patients ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ Slide 4 Parkinson’s disease - Lewy bodies • Damage results from accumulation of abnormal proteins in the neurons – Lewy bodies are found in remaining dopamine cell bodies • Protein core made up of misfolded α-synuclein ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ Slide 5 Parkinson’s disease causes • Most cases of PD are idiopathic - no identified cause – Genetic mutations, toxins, infection, head trauma and faulty metabolism functions have been identified as causes of some cases ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ Slide 6 Parkinson’s disease causes • Genetic mutations have been identified in some PD patients – Mutations result in misfolded α-synuclein and/or failure to destroy damaged proteins • Specific toxins have been linked with PD – MPTP – Rotenone, paraquat, PCBs and other agricultural and manufacturing chemicals ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ Slide 7...
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This note was uploaded on 10/01/2008 for the course PSYCH 202 taught by Professor Kim during the Winter '06 term at University of Washington.

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Damage and disorders - Slide 1 Disorders and Damage •...

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