Learning and memory - Slide 1 Learning and Memory Slide 2...

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Unformatted text preview: Slide 1 Learning and Memory ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ Slide 2 Learning • Set of processes by which experience changes the nervous system, changing behavior – Resulting changes are memories • Enduring changes to the neural circuits ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ Slide 3 Mechanisms of learning – Synaptic plasticity • Synaptic plasticity • Long-term potentiation (LTP) ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ Slide 4 Hippocampal formation - anatomy • Part of the limbic system, located in the temporal lobes • Composed of: – Dentate gyrus, CA1-3 & subiculum • Perforant pathway – Primary source of input ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ Slide 5 Experimental induction of LTP • Stimulating electrode inserted into the perforant pathway, recording electrode inserted into the dentate gyrus – Single burst of stimulation – Resulting EPSP recorded in the neuron population in the dentate gyrus ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ Slide 6 Experimental induction of LTP • To induce LTP – rapid burst of electrical pulses is delivered to the perforant pathway • To detect the presence of LTP - a single, short stimulating burst delivered to the perforant pathway, the population EPSP is measured in the dentate gyrus ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ Slide 7 LTP characteristics • Synaptic transmission more likely to cause an action potential • Lasts from several minutes to years • Can be induced throughout the brain ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________...
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This note was uploaded on 10/01/2008 for the course PSYCH 202 taught by Professor Kim during the Winter '06 term at University of Washington.

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Learning and memory - Slide 1 Learning and Memory Slide 2...

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