Learning and memory - Slide 1 Learning and Memory

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Unformatted text preview: Slide 1 Learning and Memory ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ Slide 2 Learning Set of processes by which experience changes the nervous system, changing behavior Resulting changes are memories Enduring changes to the neural circuits ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ Slide 3 Mechanisms of learning Synaptic plasticity Synaptic plasticity Long-term potentiation (LTP) ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ Slide 4 Hippocampal formation - anatomy Part of the limbic system, located in the temporal lobes Composed of: Dentate gyrus, CA1-3 & subiculum Perforant pathway Primary source of input ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ Slide 5 Experimental induction of LTP Stimulating electrode inserted into the perforant pathway, recording electrode inserted into the dentate gyrus Single burst of stimulation Resulting EPSP recorded in the neuron population in the dentate gyrus ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ Slide 6 Experimental induction of LTP To induce LTP rapid burst of electrical pulses is delivered to the perforant pathway To detect the presence of LTP - a single, short stimulating burst delivered to the perforant pathway, the population EPSP is measured in the dentate gyrus ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ Slide 7 LTP characteristics Synaptic transmission more likely to cause an action potential Lasts from several minutes to years Can be induced throughout the brain ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________...
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Learning and memory - Slide 1 Learning and Memory

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