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Describe the levels of evidence and provide an example of the type of practice change that could result from each.The levels of evidence are assigned to studies based on the methodological quality of their design, validity, and applicability of patient care. They were originally illustrated in the report onperiodic health examination in the year 1979. Randomized clinical trials were described as being the highest level of evidence because they are unbiased and also less likely to result in any systemic error (Ackley, et al 2008). This is because there is randomizing of the confounding factors which bias the results. According to the report, case series, as well as expert opinion, were considered as being the lowest levels since their high probability of being biased based on the experience of the author as well as the lack of control of confounding factors. However, this level keeps on being modified based on different settings.