ch11b-elongation-desaturation

ch11b-elongation-desaturation - fatty acids in the...

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The ER is the major site of lipid synthesis (note: elongation and oxidation also on other organelles; ER processes for synthesis of plasma membrane lipids)
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Fatty acid elongation and desaturation (oxidation) Eicosanoids
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Unsaturation by terminal desaturases electron donor 1 electron donor 2 electron acceptor (mechanism differs from mitochondrial dehydrogenase activity in β -oxidation) Voet, Fundamentals, 2nd
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Figure 25-38 The electron-transfer reactions mediated by the Δ 9-fatty acyl-CoA desaturase complex (3 enzyme subunits). Electron transport chain in the desaturation of tty acids in the Endoplasmatic Reticulum (ER) membrane
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Unformatted text preview: fatty acids in the Endoplasmatic Reticulum (ER) membrane Desaturase Cytochrome b5 Four reducing equivalents – 2 from NAD(P)H and 2 from saturated fatty acid – are used to reduce one molecular oxygen to two water molecules. (Voet, Biochemistry, 3 rd . ed.) Eicosanoid (C20 lipids) synthesis for lipid signal formation Voet, Fundamentals, 3 rd Fig. 9.12 Prostaglandin H2 synthase has a monooxygenase and cyclase activity Voet, Fundamentals, 3 rd Fig. 20.36 Non-steroidal anti-inflammatory drugs (NSAIDs) Cox inhibitors Cox-2 specific inhibitors Voet, Fundamentals, 3 rd On page 719...
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ch11b-elongation-desaturation - fatty acids in the...

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