311TakeHomefinal2006.doc - Biology 311 Human Genetics Final...

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Biology 311 Human Genetics Final Take-Home Exam (80 pts.) Due by 12 noon Wed. Dec. 13, 2006 Review to go over questions Office Hours (Denison 35, x3061) during Nov. 29-Dec. 7 or by appointment. By appointment or drop in Dec. 8, 11, 12. Available most times during the day. On separate pages, briefly type your answers to the following questions. Please double-space!! Feel free to consult the instructor if you need clarification on the questions. If you use any other references besides your textbook, be sure to cite them by author, year, title of book or journal, volume, and pages or provide the URL address for web sources. 1. (14 points) Observe the following lod score table for linkage of a disease gene to the Rh blood group locus (Rh antigen D) on chromosome 1 in a large family. Table 2: Lod analysis of linkage of disease gene to Rh blood group locus θ LOD 0 - infinity 0.05 4.74 0.10 5.44 0.15 5.35 0.20 4.89 0.25 4.22 0.30 3.39 0.35 2.49 0.40 1.54 0.50 0 a. Construct a graph of recombination frequencies (θ) vs. LOD with these data using the graph paper provided. Be sure to label the axes . b. What can you conclude about the relative location of the disease gene and the Rh locus? Are the two markers tightly linked, distantly linked or is there no evidence for linkage?
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