genetics_syllabus_spring_2006a.doc

genetics_syllabus_spring_2006a.doc - BL414 Principles of...

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BL414 Principles of Genetics Syllabus Spring 2006 Instructor Kathy S. Gleason, Ph.D. E-mail [email protected] Mailbox in the Biology office Voicemail 303-964-5731 Lecture Monday and Wednesday 2:30pm - 3:45 pm Lab Wednesday 4:00pm - 6:40pm Required textbook Recommended resource Genetics: Analysis of Genes and Genomes, Daniel L. Hartl, Elizabeth W. Jones - 6 th edition. Jones and Bartlett Publishers, Sudbury, MA ISBN 0-7637-1511- 5 Writing Papers in the Biological Sciences, Victoria E. McMillan - 3 rd edition. Bedford/St.Martin’s, Boston ISBN 0-312-25857-7 Genetics is the study of heredity – how the information governing an organism and giving it an identity and program for living is transmitted to each successive generation. Uncovering the basis of heredity led to the understanding of how genetic information is encoded in genes, and how genes encode and direct the full operating program of an organism. Today the field of genetics includes classic transmission genetics, molecular genetics and evolutionary genetics. These areas of research now reach into and intertwine with many other fields of biology, including cell biology, developmental biology and biochemistry. This course provides an in-depth treatment of genetics from the molecular to the genomic level, building on topics covered in BL260 Molecular and Cellular Biology. Students are expected to be familiar with the basics of Mendelian and molecular genetics from BL260. The objectives of the course are the following: 1) To understand the basic processes of heredity, from Mendelian to chromosomal, plus inheritance of organelles, with appreciation of important experimental organisms and with special emphasis on human genetics. 2) To understand the molecular basis of information flow from DNA, and the critical regulation of that information: how alterations in genes or regulation cause disease, how our ability to sequence genomes permits detection/diagnosis of human genetic disease, and how model organisms constructed with mutations in particular genes help decipher molecular basis of disease. 3) To appreciate the historical context of genetics and the major contributors to the field, and to investigate the social and ethical implications of these technical advances, including question of genetic privacy, gene therapy, stem cell research, and genetically modified organisms.
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Wee k: Date: Quizzes, problem sets (PS), review paper Topic: Chapters or sections in Hartl: 1 January 18 Introduction and review Ch. 1, 2.1-2.4 2 January 23 Turn in topic for review paper Transmission genetics 3.1-3.3 January 25 Transmission genetics 2.4-2.7, 3.4-3.7 3 January 30 Quiz1, PS1 Chromosomes 4.1-4.4 February 1 Statistics problems 4.5-4.6 4 February 6 Meet in Dayton Memorial Library, Room 310 Review; Library Session February 8 Test 1 5 February 13 Title, list of 15 refererences and outline of background section for paper due Linkage mapping and test crosses 5.1-5.3 February 15 Quiz2 Human pedigree 5.4 6 February 20 PS2 Tetrad analysis, Recombination 5.5-5.6, 6.9 February 22 DNA Replication and Recombination Ch. 6 7 February 27 Quiz3 Chromosome
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