Cannabis.pptx - Cannabis Chapter 11 Cannabis Three species...

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Cannabis Chapter 11
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Cannabis Three species of cannabis plant: Cannabis sativa Cannabis indica Cannabis ruderalis Potency of THC depends on part of plant: Most in the flowering tops Little in the fibrous stalks
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Cannabis Marijuana Hashish Condensed preparation that primarily contains trichome resins 2.5% of world population regular user Most common illicit substance U.S. 12 th graders report use in last year
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History of Use 2737 B.C. (China): Cannabis used to treat a number of ailments 1996 California 1 st state to legalize medical marijuana 23 states now 2012 Colorado and Washington legalize recreational use
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Pharmacokinetics Inhalation: Oral route: 50% of Δ 9 -THC encounters first pass metabolism Remaining fifty percent reaches the brain
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Pharmacokinetics Δ 9 -THC exhibits high lipid solubility Leads to rapid distribution into tissues, including the brain and accumulation in fat Δ 9 -THC in fat releases slowly over time Leads to long-term pharmacological actions and long elimination rates 7 days
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