NST10 - Fluid & Electrolyte - NST 10 Fluids and...

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Unformatted text preview: NST 10 Fluids and Electrolytes Marc K. Hellerstein, M.D., Ph.D. Professor of Human Nutrition (D.H. Calloway Chair), University of California Berkeley; Professor of Endocrinology, Metabolism and Nutrition, Dept. of Medicine, University of California at San Francisco Overview of fluids and electrolytes in the body Absolute amounts in water compartments consequences of too much or too little Systems for defending water, sodium, Outline Fluids and Electrolytes pottassium Other electrolytes and their defense Disorders of fluids and electrolytes Summary Big picture: Cells are mostlly made of water (>70%): life occurs under water The body is mostly made of water (~60-70% in children, ~50-60% in adults) Basics of Body Fluids and Electrolytes Cells have electrolytes (positively or negatively charged elements, or ions) that serve many functions The major ions inside of cells are potassium (K) and chloride (Cl) The major ions outside of cells are sodium (Na) and chloride (Cl) (blood = 140mEq/L) Simple model is as follows; About 2/3 of body water is intracellular, 1/3 is extracellular The extracellular fluid (ECF) space includes fluid around cells in tissue and Fluid compartments in the whole body includes fluid around cells in tissue and fluid in the bloodstream Fluid in tissues is about 2/3 of extracellular volume Bloodstream is about 1/3 of extracellular volume The absolute fluid volumes are therefore easily calculated; If body weight of 70Kg; non-obese 1 Kg water = 1 liter volume Fluid compartments in the whole body: Absolute volumes involved 60% x 70 Kg = ~42L body water 2/3 x 40 Kg = ~28 L intracellular water 1/3 x 40 kg = ~14 L extracellular water 2/3 x14 kg =~ 9-10 L tissue (extra- vascular) water 1/3 x 14 Kg =~ 4-5 L blood volume If lose water from, Intracellular compartment: cells shrink,...
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NST10 - Fluid & Electrolyte - NST 10 Fluids and...

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