NST10 - Lect12 vitblood

NST10 - Lect12 vitblood - Vitamin B6(pyridoxine Group of 3...

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1 Vitamin B 6 (pyridoxine) Group of 3 related compounds Coenzyme for over 100 enzymes in amino acid metabolism Required to remove nitrogen and from amino acids (transamination) Cofactor for phosphorylase in muscle - required for glycogen breakdown Cofactor for first enzyme in heme biosynthesis Vitamin B 6 (pyridoxine) Deficiency - dermatitis, anemia (impaired heme synthesis), convulsions (impaired neurotransmitter synthesis from amino acids) Good sources: enriched cereals, meat, fish, poultry, starchy vegetables Toxic in high doses - neuropathy (nerve damage) RDA 1.3 mg UL - 100 mg Pantothenic acid Component of coenzymes for fatty acid metabolism (CoA - coenzyme A) Required for synthesizing cholesterol, steroids Good sources: chicken, beef, egg yolk, potatoes, oat cereals, tomato products No toxicity from excess pantothenic acid Deficiencies are very rare (numbness, fatigue) AI - 5 mg Biotin Part of coenzymes involved in metabolism of carbohydrates, fat, and proteins Important for gluconeogenesis and fatty acid synthesis Biotin content has been determined for very few foods (very high in egg yolk) Deficiency only seen with large consumption of raw egg whites over time (avidin) Symptoms: hair thinning, hair color loss, red rash AI - 30 micrograms (synthesized by gut bacteria) Vitamin C (Ascorbic Acid) Required by primates (including humans) and by guinea pigs Deficiency: • Scurvy • Loss of appetite • Retarded wound healing • Bleeding gums and capillaries Scurvy Corkscrew hair Periungual hemorrhage Gingival hemorrhage Pinpoint hemorrhages
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2 Vitamin C (Ascorbic Acid) Functions: • Formation of collagen which is framework of bone, skin and gums • Anti-oxidant • Immune function • Hormone and neurotransmitter synthesis Vitamin C (Ascorbic Acid) • Good sources - fruit juices, fruit, spinach, asparagus • RDA - 75 mg women, 90 mg men • Doses above 200 mg are excreted in urine or
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This note was uploaded on 10/13/2008 for the course NUTRI SCI 10 taught by Professor Amy during the Fall '08 term at Berkeley.

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NST10 - Lect12 vitblood - Vitamin B6(pyridoxine Group of 3...

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