NST10 - Lect13 iron6 - Iron Most common nutritional...

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1 Iron • Most common nutritional deficiency worldwide - estimated that 2 billion people may be deficient • Excess iron also major problem as free iron is toxic and causes oxidative damage Too much Iron : a. free radical mediated damage b. susceptibility to infection c. risk of heart disease, especially in men Too little Iron : reduced oxygen- carrying capacity and energy generation - especially in women, children Free Radical : an unstable atom with an unpaired electron in its outer shell. Many factors can cause free radical formation: e.g. oxidation reactions, immune system, pollution, radiation, toxic substances Functions of Iron 1. Oxygen transport Hemoglobin Myoglobin 2. Enzyme Cofactor More than 200 enzyme reactions – Ferrous (Fe 2+ ) and Ferric (Fe 3+ ) forms 3. I mmune Function Generates free radicals Major Iron-containing Proteins 1. Hemoglobin : carries oxygen and carbon dioxide in blood 2. Myoglobin : carries oxygen to muscles 3. Cytochromes : energy generation 4. Ferritin : storage for iron, excess becomes hemosiderin 5. Transferrin : transports iron in blood Heme
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2 Iron deficiency Iron-deficiency anemia – Iron deficiency results in small red blood cells (microcytic) that do not contain enough hemoglobin – Symptoms are fatigue, pale skin, impaired
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This note was uploaded on 10/13/2008 for the course NUTRI SCI 10 taught by Professor Amy during the Fall '08 term at University of California, Berkeley.

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NST10 - Lect13 iron6 - Iron Most common nutritional...

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