Spring 2006 MT 1

Spring 2006 MT 1 - BIPN 102, MAMMALIAN PHYSIOLOGY 11 NAME:...

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Unformatted text preview: BIPN 102, MAMMALIAN PHYSIOLOGY 11 NAME: gm 2 Spring 2006 lst MIDTERM EXAM I.D. # April 27, 2006 Page 1 1. (16 points). Fill in the following table by marking an “X” for which muscles are contracting for each set of intrapleural and alveolar pressures, and an “I” or “E” or “0” under airflow to indicate inspiration, expiration or no airflow, respectively. If not possible, briefly indicate why. If abnormal, indicate which condition exists. Assume you are at sea level. m}. “L mpi’ 2 for M4 P099 [M4 PIP = 757 PIP = 757 PIP = 734 PIP = 790 PIP = 760 PIP = 760 PA = 761 PA = 760 PA = 742 PA = 797 PA = 757 PA’ = 760 _ — _ — - _ m _ _ 2. (14 points). The graph below shows spirometer traces for a normal subject and two different patients with advanced pulmonary disease with abnormal lung compliances. Indicate which curve belongs to the normal subject and which curve belongs to the patient with increased compliance and which with decreased compliance, and give an example of a possible cause (not the type of disease) of the abnormal compliances. ~ [3 ._ “‘54 Co lumcg q l‘3 9,. Iu‘efi OF QKQHC C : DEW» CoHQuMIGE 4P+5 5‘3 Mew collagen a??? 0"“sz lack 5"“ 0i” W SR0“ M 3. (12 points). A scuba diver is breathing a mixture of helium and oxygen that reduces the viscosity of the gas to ‘/2 of that of air. The tube he is breathing through increases the total length of his airways to triple the normal length. While diving he develops an asthmatic attack that constricts his bronchioles to Inspiration Expiration 43D 1/: of their normal radius. Calculate by what factor his alveolar pressure must chapge to #:aintain tlf same airflow as beforeW w "0 9C” Kflu-r‘ 69*? Flow ; AP, ‘IT'r‘l (6 WW x256 foe futilf 4‘? gall Atoms xz For “5‘3: I . mm K3 PM W $0 W 394-9014. 15-6 ’3 : lzerg 23841 6 9+5 awco‘l' 2. BIPN 102, MAMMALIAN PHYSIOLOGY 11 NAME: ANS gag KEy Spring 2006 lst MIDTERM EXAM 1.1). # Aqn1127,2006 Page2 4. (14 points). The graph below shows spirometer traces of forced expirations for a normal subject and two different patients with advanced pulmonary disease. Indicate which curve belongs to the normal 1V subject and which curve belongs to the patient with a restrictive disease and which with an obstructive disease, and give an example of a disease that causes each abnormality. :2 2 '3 l1 393' 11 sec] FEV: 1.3 FEV= 2,8 FVC = 3.1 FVC :: 3,1 % = 42 0/, = 90 VE 3 Cf“ W. AWHHAfiHPth’sEHA Fiaeosu W at. war of Surime Li 9‘3 I ammrkL/fl 5. (12 points). Russell Peters, while hiking, had an anaphylactic reaction to some weird plant in the mountain; his glottis closed and he was given a tracheostomy, thereby decreasing his Vdead space from {r- 150 mL to 80 mL. His total ventilation before the reaction was 5.5 L/min and his respiratory frequency Q was 10/min. i» A. What will happen to his alveolar P02 and Pcoz if he maintains the same total ventilation? a (V702, M?“ T, R»; W!” Jr hem «km!» vwhiai'ioa’iw‘i‘h swu- ngfip "H B. In order to prevent any changes in his alveolar P02 and Pcoz , what must be his new tidal volume if his respiratory frequency remains the same? Show your calculations. V ;L5§O"SD>IO 5 qL/rm'u k {L A " . 9* To w»an VA I V110 hwy!- Juy-ease '70 430 M V» : (490403!” 91 410%. BIPN 102, MAMMALIAN PHYSIOLOGY 11 NAME: M’ '6 Spring 2006 lst MIDTERM EXAM I.D. # April 27, 2006 Page 3 6. (14 points). Mr. Climbalot climbed all the way to the top of Mt. Everest where the Pm = 250 mm Hg. A. Calculate his P102: : (25!) —‘-l'7>-0.Zl :; ‘43 MM 141$ ‘ipl; B. Calculate his PA02, assuming that his PAC02 is the same as at sea level,that his diet is only starches (e.g., white bread), and his alveolar ventilation is the same as at sea level: pAoz; (Pi—0"" Egg :2 ‘(3 -_‘/TD_.: 3 mml‘b éelio aw C: Calculate his PAOz, assuming that his PAC02 is 15 mm Hg owing to hyperventilation. “PW,— 43 12? 3 28 MN? I zplo 7. (16 points). Indicate whether the following would result in constriction (C) or dilation (D) of the \L pulmonary arterioles or bronchioles: \I’f Pulmonary Arterioles Bronchioles 6 Increase in PAO2 b l 14. it. (v 0 ¥ C Onsfi'flo‘l' b I IQ Jc 'Q V/Q < 1 4- 2" At the top of the lung of b l {‘12 Coats i‘r‘o a person standing up + In a section of lung where D 1 COWS {Vlb a tumor decreases blood flow Fill in the blanks: The diameter of bronchioles is also controlled by the autonomic nervous system. Parasympathetic 0 I . activation results in m, V1a the y mg; Nag v5 whlch releases Mn 105 425‘}, pm "g receptors. Bronchioles are not directly innervated by sympathetic nerves, but instead have Mecceptors which bind epl 5e m released from the , resulting in 112 [ LA’T’ W . BIPN 102, MAMMALIAN PHYSIOLOGY 11 NAME: Afigflgfi’ Kg” Spring 2006 lst MIDTERM EXAM I.D. # April 27, 2006 Page 4 8. (14 points). A patient comes in to your office with the following lab data: Vtidal = 500 mL y FRC = 2300 mL Vital Capacity = 3900 mL Residual Volume = 1200 mL Alveolar P02 = 100 mm Hg . Arterial P02 = 80 mm Hg (0 a. Which values are abnormal in this patient, if any? 33:? 4» $17701 CAI/MTV I5 Décxeaaén Beam/5E 0F 0 179 V 0 lb 050 b. Wliiit 125' the most likely diagnosis, if the patient is not normal? Why? (Use the data to support your answer) PULMONka SFtaeosis WOULD 966% IRV Mamie af— IMJAJ‘HC 9&6 l2 . 9 - ‘ 14 +10% k #4 bl d w. ‘3' %k§f€k%5qsuov Increase. u: was; dF oo 5a; MW e. Write Fick’s equation for the flux of gas. Which of the terms in the equation do you expect to change, if any, based on the diagnosis you made above? Flux: Apgas .%~ . T'th‘okhbss a)!” J, Flux 3 ed bKP' 9. (10 points) On the hemoglobin-oxygen dissociation graph below, draw the following: a. The normal Hb-O2 dissociation. Label this “Normal”. b. The curve for someone with CO poisoning, where CO occupies 60% of the hemoglobin binding ' \L sites. Label this “CO”. 6 c. The curve for someone with anemia. Label this curve “A”. Q, d. The curve for someone with a metabolic acidosis. (High concentration of H+ in the blood.) Label this e. The curve for fetal hemoglobin. Label this “C”. 100 t) 9" 7/00” 75 50 CO 7.02m 25 25 50 75 100 P02 (mm Hg) / BIPN 102, MAMMALIAN PHYSIOLOGY 11 NAME: ANSWCY’L Spring 2006 lst MIDTERM EXAM I.D. # April 27, 2006 Page 5 10. (14 points). Diagram the pathway, reactions, and ion movements that C02 undergoes upon entering a systemic capillary. Indicate the substrates, products, enzyme and transporter involved. “$1 1. (12 points). A. List the location in the CNS of the following groups of neurons: g“ Inspiratory neurons: M63 “Ll-r“ 1&5 Expiratory neurons: Mam)" L A 6}“ Phrenic nerve motoneurons: CERVICAL sPWM- CW Rab Pneumotaxic Center: (1)0 N S B. What will happen to the respiratory frequency and depth if the pneumotaxic center is destroyed in an anesthetized animal? Réfiotflfimfiy FREQueMC)! UNcHI‘rNGC-Tb 2 45 'D INSPiRATIon/j PetA betm iNceenseb Joe ‘10 ’PRochfl: ...
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This note was uploaded on 10/13/2008 for the course BIPN 102 taught by Professor Nefzi during the Spring '06 term at UCSD.

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Spring 2006 MT 1 - BIPN 102, MAMMALIAN PHYSIOLOGY 11 NAME:...

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