Pharmacodynamics1

Pharmacodynamics1 - Pharmacodynamics How medications work...

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Pharmacodynamics: How medications work on the body
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Receptors: Different types: large protein molecules found embedded in the cell membrane those that are found within the interior of the cell. All receptors have in common that they have binding specificity The specific neurotransmitter is in most cases the best fit for its specific receptors but drugs can mimic these molecules to interfere with or modulate the action of the neurotransmitters.
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How well the molecule “fits” with the receptor site is referred to by the term affinity . The molecule with the best fit is going to have the highest affinity. If when a molecule binds with the receptor it is able to initiate a biological action then the molecule is referred to as having efficacy . How potent a drug is is defined by the absolute amount of the drug needed in order to produce a specific effect.
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Types of drug action: Agonists and Antagonists Agonists bind to receptors by being similar enough to the neurotransmitter that it mimics its effects. A drug that acts as an agonist will have affinity for specific receptors sites and will also have efficacy. Typically drugs have a varying level of affinity (dependent upon the drug molecule but to act as an agonist, will have a high degree of efficacy. This does not mean that the drug is necessarily exciting the
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Pharmacodynamics1 - Pharmacodynamics How medications work...

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