Key-final

Key-final - 2 Name (Last, First} . i l. Deacribe the In]:...

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Unformatted text preview: 2 Name (Last, First} . i l. Deacribe the In]: ofthe: E and F helix in hemoglobin for the proper functinning 0f humuglnbin? 31:} E34; W7: MAME—345k? E, mm WERE 31) 0:. WW3 :1 Mm Mow WW“’”‘“‘" “31 'T r‘? Q 3% (IN LW} PIS/WW 09M“) 2. Indicate which ofth: following peptides can be cleaved by ttjrpsin andfor chymutrypsin and indicate the site afhydrulysis. 3U ASRkVSTYk + WWI WM LVKFMEIFFSG 0', M 4r 0k WW I! I" '61} h'h MTVLF‘MPR mu 14} V1 3 Name (Last. First] Q mm RJ‘t'ridiy'.’ Give two examples. 3U 4. mam-film}? [2} Structural features of phosphelipids that are known to influenee the melting temperature of biiuyers and indicate in which way they would decrease the melting temperature. 3t] 4 Name (Last, First] El: 5. Draw the topology diagram of a voltage gated K-ehannel and indicate all possible locations for N—linked glyeosylation ofthis cell surface membrane protein. What Signature amino aeid sequence would you need to irlentifilr to confirm sueh potenlial glycosylation sites? all} 6. Draw a Ramaehandran plot and indicate the approximate Ionization of the right handed alpha-helix. How does this compare to poseible torsion angle values for glyeines in random loop struetures‘? [Label both axes properly}. 3o 5 Name (Last. First] it. What is the postulated functien of Arg and Lys residues {11] the non helical dcmains at the N-terminus c-i‘ histnne 3 and histc-ne 4‘? Name the pncttranslatinnal modification invc-lved in their function. 4|] r hm... MAN, (Liv/H WM ' j W“ “i ifl—M M)" -r aqu‘vi it. Someone argues that a specific RNA polymerase subunit called TAP (TBP associated factor) may he int'ttlved in DNA binding independent orthe actual DNA Sequence. Based {in the cumparifitm In which protein famin might Such an argument he riictiic'.J 3U 5 Name (Last. First] 9. Bacterial flagella basal bod};r structures are an example ol‘n‘idlecular motors. Describe its architecture {subunit composition} at the inner membrane and the use of energy source. {No explanation of mechanism needed.) 31] Ms M Em fab/k5 _ 14+ gmnwi '3‘; WNW WELL) lfl. CDRs determine antigen binding specificity of IgGs. As CDRs are part of the variable domains oflgGs, what variability is meant here?I How does this variability translate into antigen binding diversityr despite the observation that the backbone conformation of the beta—strands Ibund in variable domains is actually conservad'.’ 3t} “\im-iaGQ/i "i5 0%. -Utu‘h text talk ikmés a M awake/c Mai-Lat at: Miarwd T Name (La st. First) J64: ’ l I. What is the enzymatic aotiwit}r ofepidetma] growth factor receptor (EGFR) and what is the activation mechanism? 4D ‘i‘JflrimL-WRR rat/immith We‘f “EMMA (ii/M“ W or? 12. What is the role of the M2 transmembrane segment in nieotinie aeetyichotine receptors? identify the amino acid residue in this segment that allows sodium and potassium but not chloride ions to pass through this charmel. 4i} it Name (Last, First] a a: 13. Describe the t.CI1:|I::ilt:rg_'¢ur diagram Ufa G-prutein coupled reeeptur sueh as CCRS. Indicate inside. outside, and N—snd lC—t-:=:rn*ninsl ends. What is the seenndsw structure 0f the transmembrsne segments? What is the role ut‘CCRS in HIV inl'eetiun'? 4G 1 V M I4. Describe the domain eompusitinn Ufa T-eell reeseptnr. How is this structure similar to ngUr‘:1 4i} Ema-Rn: ML ML WWW-$35: Mas 5m '?;E_;J:£:flr (’1 (fig) s Name (Last. Hang—#— 15. Which ey’toskeietal proteins are part of the major structure of eukaryotie eilis'? energy source is used to form these structures and which enet'gg,r source is needed by dynein for the movement nFthese cilia structures? 3t] d nun-L [F ‘l‘AEi'WLQS 16, Give two examples of Zn binding proteins and the role of the metal ion. 3t] Cmt3m_____n,nm .s an? ua 2:! cu “gag? g Wit/131%ng —* asset W s me; We 1D Home {LasL First} :- lT. How does elevated cfiosolic calcium activate the plasma membrane calcium pump? a Cmflxfl Cmtfit I 0,. Wsflifiim Dimitri di- lb“ Wt 13. The hydrophobic effect is called an *entrop}? driven' effect. What does this mean? Use protein Folding as an example. Why does the entropy of the folded protein itself become more negative during this process?I 3G Wilma“; M W 0W ...
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Key-final - 2 Name (Last, First} . i l. Deacribe the In]:...

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