04 BIBC100-midterm2

04 BIBC100-midterm2 - \N mg“ 2 Name(last first PLEASE READ THE QUESTIONS CAREFULLY BEFORE ANSWERING The transition temperature of a bilayer

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Unformatted text preview: ._ \N mg“ 2 Name (last, first) : PLEASE READ THE QUESTIONS CAREFULLY BEFORE ANSWERING! . The transition temperature of a bilayer depends on the molecular structure of PC and PE. Which of these two phospholipid types, based on the headgroup. would induce a higher transition temperature? What feature in their fatty acid constituents would favor such a higher transition temperature? Name a fatty acid that conforms to your explanation. 30 points re (y watt My MM 60 We QM / (Coho) 2. Name a cytoplasmic homopolymer used for energy storage containing branched strands of glucose units. What glycosidic bonds are found in this macromolecule? Which of these glycosidic bond types causes helical strand conformation? 40 points 390% w WWMk 69 adv“) 0:34 0‘0"“ Q9 i MOM W (MM/{4W 3. You identify a mutant hemoglobin that only forms a ‘T state’ but is unable to switch to an R conformation. What p50 (higher or lower) compared to normal hemoglobin would you expect in this T-state mutant? What Hill coefficient n would you measure? How would this mutant hemoglobin compare to myoglobin oxygen affinity? 30 points it»: w 69 \A;\ ' t {cm}? W WDOML‘ @ 0, 0w»! O W QCD 3 Name (last, first) : '3' 4. Name the oleea-la-r components of the glycan portion of bacterial peptidoglycan. What chemical bond type connects these monomeric glycan units in the polymeric form? What is the role of glycines in this cell wall heteropolymer? 30 points 5. Transfer RNA molecules are important structures fo She tran lation of the genetic code. Describe 1ts four—domain structure and 1nd1cate which ones con ribute d1rectly to 1ts abllity to convert a nucleic acid into an amino acid sequence? Which enzyme class provides the actual mechanism for tRNAs in determining their specificity? 40 points Qt 0m -) W W“ /@ “H c mm mm 001x (I) i ‘ (awioatfil “Ml HALE“ ® 6. Enzyme - Substrate complex formation (BS) is an important component to understand enzyme catalysis. Which constant in enzyme kinetics is used to quanti y the stability of this complex? Give the definition of this constant.( \WN l3 WWW“; 30 points KW N WlJAAM—MQWM Q9 (it: “AM .MW‘M “4 “ill/WAX ("9 ' Q9 w (who/Mm 4 _ Name (last, first) : ' \ A 7. Name the 4°D and12°D structure of bacterial porinsé Based on the 2°D structure and the observed distribution of water molecules in each porin subunit, what distribution/sequence requirement would you expect for polar and non-polar residues? , 30 points «awe:- - 8. Explain why a hydration shell prevents the movement of ions across a lipid bilayer. How does an ion channel like the nicotinic acetylcholine receptor exploit this mechanism to control when and if monovalent cations can cross through its pore? 30 points v‘k (Wu) {a wow «LC/Wk) A (Hikjpl DWI Wu la (n levl; wwwm» fawn/v; KM iABM‘iW M l3 0\ XM’UE} me‘g M CnMW+6‘i0V~UCMM¢Q MM RM WV‘ 0“ W WWN lxvlmfllut) emit m MACLtK WW 0x VDKNWmLM' (WW/*1} WM” W” i‘y‘ “NV”; ' l1“ MM HMAWKMM “WAF'WW'L’ ovum; A WA +0 MAva 'T . \L’ «M 5 Name (last, first) : ‘ 9. Why would a mutant calmodulin with a dissociation constant of lOnM not be functioning as a calcium sensor under physiological conditions? (Physiological range of Ca concentration is 100 to SOOnM). 40 points «KM wl’MJr GM est/NM 0t WW i» G: a $24,500, CA/Cwm LAG/LIL “AK (‘0 » W M at 01 amt; Ch MMK @ ...
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This note was uploaded on 10/15/2008 for the course BIBC 100 taught by Professor Nehring during the Summer '07 term at UCSD.

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04 BIBC100-midterm2 - \N mg“ 2 Name(last first PLEASE READ THE QUESTIONS CAREFULLY BEFORE ANSWERING The transition temperature of a bilayer

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