311C_F08_chapter 5 p 4 - phosphodiester linkage linkage...

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Nucleic Acids Chapter 5 (Pages 86 – 89)
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The roles of nucleic acids There are two type of nucleic acids Deoxyribonucleic acid (DNA) Ribonucleic acid (RNA)
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1 2 3 Synthesis of mRNA in the nucleus Movement of mRNA into cytoplasm via nuclear pore Synthesis of protein NUCLEUS CYTOPLASM DNA mRNA Ribosome Amino acids Polypeptide mRNA
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The chemical composition The chemical composition of DNA of DNA polymer polymer , made of repeating units units are nucleotides nucleotides nitrogenous base base deoxyribose sugar phosphate phosphate group
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Each polynucleotide Consists of monomers called nucleotides Nitrogenous base Nucleoside O O O - - O P CH 2 5’C 3’C Phosphate group Pentose sugar (b) Nucleotide O
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Assembly into a Nucleotide : Assembly into a Nucleotide : Linkage N-1 to C-1’ Linkage N-9 to C-1’ Base and Sugar Base and Sugar Base + sugar + phosphate
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Nucleotides polymerize via
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Unformatted text preview: phosphodiester linkage linkage between nucleotides consists of a phosphate group linked to 2 sugars through a phosphodiester bond phosphodiester bond gives DNA polarity polarity always a free 5-PO 4 2-and a free 3-OH end 5-end 3-end A C G A T C Oligonucleotide Polynucleotide DNA is double-stranded, with c omplementary base pairing . RNA: Fig. 5-UN2a Fig. 5-UN2b Main concepts Know the relation between DNA, RNA, proteins Know the difference between nucleosides and nucleotides. How do these differ between DNA and RNA? Know to recognize structures of A, G, C, T and U Understand the concept of complementarity. Be able to write complementary DNA and RNA sequence with correct polarity...
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311C_F08_chapter 5 p 4 - phosphodiester linkage linkage...

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