ProbSet3key_000

ProbSet3key_000 - Problem Set 3 BIBC 100 WI08 1. For each...

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Problem Set 3 BIBC 100 WI08 1. For each of the following amino acid substitutions, indicate if they would be apt to cause a change or disruption of protein structure and explain your answer. Ala to Gly no change likely - both small hydrophobic residues Leu to Lys change likely –Leu is hydrophobic and Lys is large and positively charged Asp to Glu no change likely – both similarly sized negatively charged residues Val to Tyr change likely – Val is small hydrophobic and tyrosine is larger and has a polar OH group 2. Which of the following peptides do you think would form a more stable alpha helix and why? #1. A – V – R – M – W – V – E – L – S #2. R – K – R – W – Q – K – R – M - H – W Peptide #1 is likely to form a more stable helix since all of the residues in helix #2 are large and bulky which could lead to steric hinderance between side chains. Furthermore, there are large residues with the same charge 3- 4 residues apart , which will lead to electrostatic repulsion of side chains. 3. You have just completed a mass spectrometry experiment and you have
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ProbSet3key_000 - Problem Set 3 BIBC 100 WI08 1. For each...

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