stemcells - Stem cells possess 2 main characteristics:...

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Stem cells possess 2 main characteristics: -Long-term self renewal. - They give rise to all types of differentiate cells. From inside out: -the inner cell mass – about 30 cells; -the blastocoel; - the trophoblast . The stem cells which have the greatest differentiation capacity are: 1. Totipotent. 2. Pluripotent. 3. Multipotent. Sources of pluripotent stem cells: -The inner cell mass of the blastocyst. - Fetal stem cells.
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Diseases that might be treated by transplanting cells generated from human embryonic stem cells include: -Parkinson's disease -Diabetes -Traumatic spinal cord injury -Purkinje cell degeneration - Duchenne's muscular dystrophy -Heart disease -Vision and hearing loss Embryonic stem cells have broader differentiation potentialities. They can give rise to any differentiated cell type. Adult stem cells, like hematopoietic or nerve stem cells, can only give rise to hematopoietic or nerve cell types, respectively. Examples of differentiated blood cells: -red blood cells (erythrocyte) - white blood cells (lymphocyte T, lymphocyte B, macrophage, neutrophil, etc) -platelet Totipotent stem cells are cells that can become any kind of cell in the body. “Toti” comes from the Latin word “totus” or “total”, so you can think of a totipotent stem cell as having “total” potential. Early embryonic cells are totipotent.
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Feeder cells release nutrients and growth factors into the cell culture which ‘feed’ and support the stem cells. Embryonic stem cells are
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This note was uploaded on 03/19/2008 for the course ISB 204 taught by Professor Stolfuz during the Spring '08 term at Michigan State University.

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stemcells - Stem cells possess 2 main characteristics:...

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