chap15-Metabolism-slides - Metabolism Chapter 15.1-15.4...

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Metabolism Chapter 15.1-15.4 • Metabolism is composed of many coupled reactions • ATP • Oxidation of carbon fuels • Metabolic pathways contain many recurring motifs and chemical reactions
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How does a cell extract energy and reducing power from its environment?
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Glucose Metabolism Chapter 15
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Glucose Metabolism Reaction/Pathway Requirements: 1. Specificity 2. Thermodynamically favored Catabolism Anabolism Are usually distinct in part
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Δ G of chemically coupled reactions is the sum of the changes of the individual reactions A B + C Δ Gº = +5 kcal/mol B C + D Δ Gº = -8 kcal/mol ____________________________ A C + D Δ Gº = -3 kcal/mol
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Coupling ATP hydrolysis to unfavorable reactions ATP + H 2 0 ADP + P i Δ G = -7.3 kcal/mole A + B C + D Δ G = + 4 kcal/mole A + B +ATP C + D +ADP + P i Δ G= -3.3 kcal/mole
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G and K eq A + B C + D K eq = ([C][D]/[A][B]) G = G° + RTln([C][D]/[A][B]) K eq = e - G°/RT K eq = e - G°/2.47 = 10 - G°/5.69
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This note was uploaded on 10/20/2008 for the course BIOLCHEM 415/515 taught by Professor Ballou during the Fall '08 term at University of Michigan.

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chap15-Metabolism-slides - Metabolism Chapter 15.1-15.4...

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