P.E.T(1).pptx - Hypertension in Pregnancy Background Occurs in about 5-10 of pregnancies Associated with significant maternal and perinatal mortality It

P.E.T(1).pptx - Hypertension in Pregnancy Background Occurs...

This preview shows page 1 - 10 out of 25 pages.

Hypertension in Pregnancy
Image of page 1
Background Occurs in about 5-10% of pregnancies Associated with significant maternal and peri- natal mortality It has a wide spectrum of presentation, rang- ing from minimal elevation of blood pressure to severe hypertension with multiple organ dysfunction.
Image of page 2
Classification Gestational hypertension: HTN without pro- teinuria at > 20 / 40. Preeclampsia: HTN with proteinuria at > 20 / 40 Eclampsia: Convulsions in a patient with P.E Chronic HTN: HTN < 20 / 40, persists for > 6 / 52 postpartum Superimposed Preeclampsia: Preeclampsia in a patient with previously diagnosed hyperten- sion.
Image of page 3
PREECLAMPSIA Gestational hypertension plus proteinuria > 20 / 40 A pregnancy specific multisystem disorder characterized by HTN and proteinuria associ- ated with end-organ dysfunction due to organ ischaemia.
Image of page 4
Aetiology: Cause unknown Disease of theories: Several theories regarding etiology • Abnormal placentation • Immunologic phenomena • Coagulation abnormalities • Abnormal cardiovascular adaptation • Dietary factors • Genetic factors • Angiogenesis factors • Vascular endothelial damage • Abnormal prostaglandin metabolism
Image of page 5
Epidemiology It affects 6% to 17% for healthy nulliparous women. Affects 2% to 4% for multiparous women. 75% of patients with preeclampsia develop the disorder at ≥37 weeks of gestation.
Image of page 6
Risk Factors Nulliparity Extremes of maternal age Multiple gestation Genetic predisposition Previous pregnancy with preeclampsia Family history of preeclampsia or eclampsia Preexisting hypertension or renal disease Pregestational diabetes Use of donor oocytes Nonimmune hydrops fetalis Molar pregnancy Obesity
Image of page 7
Pathogenesis of Preeclampsia Maladaptation to pregnancy Poor placentation Placental Ischaemia Placental Oxidative Stress Release of vasoactive factors Diffuse maternal Endothelial damage .Vasospasm .Abnormal capillary permeability .Abnormal Clotting activation
Image of page 8
Etiopathology of Preeclampsia
Image of page 9
Image of page 10

You've reached the end of your free preview.

Want to read all 25 pages?

  • Winter '16
  • Bill Oyieke

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern

Stuck? We have tutors online 24/7 who can help you get unstuck.
A+ icon
Ask Expert Tutors You can ask You can ask You can ask (will expire )
Answers in as fast as 15 minutes