2103491379 - Review Aids for Lecture 8 Understand...

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1 EXTRACELLAR MATRICES Lecture 8: Chp. 7 Review Aids for Lecture 8: Understand compositional differences between glycocalyx, basement membrane, cartilage. How does fibronectin and laminin contribute to embryonic development? Functional role of integrins, importance of RGD motif. Structural and functional differences between hemidesmosomes, desmosomes, gap junctions, adherens junctions, tight junctions. Similarities of gap junctions and plasmodesmata: in both plants and animals? What are primary components of cell walls? Distinction between secondary vs. primary cells wall? Where are EMC synthesized, modified where, and how localized to outside how? Example of role of cell adhesion in inflammation Terms: microfibrils, cell plate, pectin, collagen, actin, cadherin, immunoglobins, connective tissue Why study ECM-Extra Cellular Matrices? Cells interact with extracellular matrices & interact with other cells to form tissues. Important for: cell migration, growth, differentiation and organization during embryogenesis. Cell coat is a glycocalyx (carbohydrates projecting from cell surface, in animals have basal membrane connection) – prominent in epidermal cells - skin, secretary ducts, intestine, lung, etc., signaling Provides mechanical & dehydration protection, strength, cell shape maintenance – particularly in plant cells and unicells. Mucigel sheath Plant seedling root growing through soil Root hair tip EM: secretory vesc. (Taiz & Zeiger 03 Plant Physiol.)
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2 Extracellular Matrix of Intestine Site of Glu-Na + cotransport - intestinal microvilli Specialized support and contacts between cells (not composed of cells) (Secrets collagen & extracellular matrix material) Basement Membrane Characteristics • not a cell-containing layer •anchoring function • 50-200 nm thickness, dependent on tissue type • surrounds muscle and fat cells • underlies epidermis • underlies blood vessel
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2103491379 - Review Aids for Lecture 8 Understand...

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