2110500911

2110500911 - Lecture 9. Cytoskeleton & Motility Ch. 9 and...

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Lecture 9. Cytoskeleton & Motility Ch. 9 and Metabolism: Glycolysis Ch. 3 p. 108-120. The traits and functions of major cytoskeletal elements Intermediate filaments Microtubules Microfilaments The general mechanism by which molecular motors move along cytoskeletal elements The structures and functions of specific molecular motors: Dyneins Kinesins Myosins Microtubule organizing centers (MTOC), their structures and functions Dynamic properties of cytoskeletal elements and how this relates to their construction and functioning Basic structure of cilia (shorter) and flagella (longer) the same with axoneme of central microtubules, both covered by membrane. Functional difference? The basic mechanism of muscle contraction The importance of nonmuscle motility Techniques used to study the cytoskeleton Review of the processes of Glycolysis, and anaerobic fermentation Glucose breakdown, energy gain NAD, NADH NADP, NADPH Coupled reactions
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1 Cytoskeleton and Cell Motility Chp. 9 AND Metabolism: Glycolysis Chp. 3 Cytoskeleton is composed of 3 types of fibrous structures: 1. Intermediate filaments- desmosome attachment, strength 2. Microtubules – stiff hollow tubes 3. Microfilaments (actin filaments)-adherens junct. Major motor protein families associated with cytoskeleton: Kinesin – movement along microtubules Dynein – movement along microtubules Myosin – movement along microfilaments (actin) Interlinked microtubules and intermediate filaments Protein linker Intermediary filaments – tough ropelike fibers composed of a variety of proteins. For strength in muscles neurons, epithelial cells. So far only in animals (keratins, lamins – under nucl. membrane) Non polar 10 nm wide. Strength and durability against mechanical stress
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2 Microtubules in Cell Shape Determination Dynamic microtubule functions in plant cell cycle Chromosome movement Transverse aligned- cell division Cell plate formation In cortex cell structure MICROTUBULES DETERMINE CELLULOSE MICROFILAMENT ORIENTATION IN PLANTS MICROTUBULES CELLULOSE Microtubules (red) role in organelle peroxisomes -green) movement cell
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3 Microtubules : long hollow tubes (25 nm) composed of tubulin protein polymers. For support, intracellular
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This note was uploaded on 10/22/2008 for the course BSCI 207 taught by Professor Higgins during the Spring '08 term at Maryland.

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2110500911 - Lecture 9. Cytoskeleton & Motility Ch. 9 and...

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