Quiz 8 Some Useful Info

Quiz 8 Some Useful Info - HormoneAmplificationCascade 1.)

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Hormone Amplification Cascade 1.) Epinephrine binds to receptor protein in the plasma membrane 2.) Activated receptor leads to activation of ~10 adenylate cyclase 3.) Each active adenylate cyclase enzyme yields ~10-100 cAMP 4.) ~4 cAMP active 2 catalytic sites of protein kinase A enzyme a. Note: THIS STEP DOES NOT AMPLIFY SIGNAL 5.) Protein Kinase phosphorylates several enzymes (and targets serine residue) a. Glycogen Synthase – inactivates it, stops synthesizing glycogen b. Phosphatases – inactivates it, enzyme responsible for inactivating GP c. Phosphorylase Kinase - activates it 6.) Each activated phosphorylase Kinase activates ~100 glycogen phosphorylase b 7.) Each active glycogen phosphorylase a now acts on glycogen to form ~100 molecules of product, G-1-P Note: 1 Epinephrine ~10^7 G-1-P GP – Glycogen Phosporylase - With phosphate GPa, without GPb - High [glucose] GPa into T-state (inactive) - High [AMP] and low [G-6-P] GPb into R-state (active) Activators: AMP Inhibitors: ATP, Glc, G-6-P
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This note was uploaded on 10/23/2008 for the course BIOBM 3310 taught by Professor Feigenson,gw during the Fall '07 term at Cornell.

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Quiz 8 Some Useful Info - HormoneAmplificationCascade 1.)

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