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Unformatted text preview: Avoid suicide by apoptosis Bypass limitations to proliferation (telomerase) Sustained angiogenesis (make new blood vessels) Able to invade other tissues (metastasize) Problems with treatments Cancer cell vs normal cell Drug delivery Several targets Multiple mutations Fast growing Need to kill all cells Actual Treatment? Angiogenesis Telomerase Surgically remove cells Block cell division Damage DNA Use ionizing radiation and drugs o Hope that: Normal cells will stop cell cycle to repair DNA Cancer cells wont stop replicating and wont repair and die from DNA damage Chronic Myelogenous Leukemia Philadelphia chromsome -> results in BCR-Abl fusion protein o This fusion protein will stimulate a number of cell cycle controlling proteins, speeding up cell cycle...
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This note was uploaded on 10/25/2008 for the course BIMM 100 taught by Professor Pasquinelli during the Fall '06 term at UCSD.
- Fall '06