Ch_14_ECM - ECM Dense fluid in which there are a lot of...

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ECM Dense fluid in which there are a lot of cells Collagens: o Stiffen fibers in ECM o AA sequence is G-X-Y (consensus XY is Pro, hydroxypro) o Every 3 rd residue has a twist o Assemble in ER and golgi, follow default secrotory pathway Procollagen has N+C termini still, after secretion from cell termini are cleaved and collagen can form fibrils. o Vitamin C needed to hydroxylate lys and pro to make collagen. (SCURVY) o Molecules of collagen form fibrils via S in lysines of two molecules. Elastin: o Secreted from cells as soluble tropoelastin monomers o Elastic fibers formed from elastins crosslinked by bonds b/t side chains of lysines. o Desmosine and isodesmosine also involved in cross-linking Unique AA formed by lysine amino oxidase Fibrillin o Usually found where elastin is found o Cysteine rich, many S-S bonds o Defect- results in Marfan’s syndrome Matrix Adhesion Proteins Fibronectin o Dimers that result from alternative splicing o Principal adhesion protein of connective tissues o Has binding sites for collagen and glycosaminoglycans, crosslinks the
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This note was uploaded on 03/19/2008 for the course MMG 409 taught by Professor Arvidson during the Spring '08 term at Michigan State University.

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Ch_14_ECM - ECM Dense fluid in which there are a lot of...

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